ID   MUTS_CLOP1              Reviewed;         910 AA.
AC   Q0TRD6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=CPF_1358;
OS   Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB
OS   6125 / NCTC 8237 / Type A).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=195103;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / S 107 /
RC   Type A;
RX   PubMed=16825665; DOI=10.1101/gr.5238106;
RA   Myers G.S.A., Rasko D.A., Cheung J.K., Ravel J., Seshadri R., DeBoy R.T.,
RA   Ren Q., Varga J., Awad M.M., Brinkac L.M., Daugherty S.C., Haft D.H.,
RA   Dodson R.J., Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S.A.,
RA   Khouri H., Dimitrov G.I., Watkins K.L., Mulligan S., Benton J., Radune D.,
RA   Fisher D.J., Atkins H.S., Hiscox T., Jost B.H., Billington S.J.,
RA   Songer J.G., McClane B.A., Titball R.W., Rood J.I., Melville S.B.,
RA   Paulsen I.T.;
RT   "Skewed genomic variability in strains of the toxigenic bacterial pathogen,
RT   Clostridium perfringens.";
RL   Genome Res. 16:1031-1040(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000246; ABG82875.1; -; Genomic_DNA.
DR   RefSeq; WP_011590676.1; NC_008261.1.
DR   AlphaFoldDB; Q0TRD6; -.
DR   SMR; Q0TRD6; -.
DR   STRING; 195103.CPF_1358; -.
DR   EnsemblBacteria; ABG82875; ABG82875; CPF_1358.
DR   GeneID; 29571529; -.
DR   KEGG; cpf:CPF_1358; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001823; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..910
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008054"
FT   BINDING         615..622
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   910 AA;  103104 MW;  6E53AD268CC40E4E CRC64;
     MKLTPMMRQY FEIKENYKDC ILFFRLGDFY EMFFEDAETA ARELELVLTG RDCGLEKRAP
     MCGIPFHASN SYIGRLVAKG YKVAICEQVE DPKFAKGIVK RDVIKVITPG TYTDSSFVEE
     TKNNYIMTIY ADLERNRCSL AITDISTGDF LATEGELEKG VILDEISKFN PKEIILLDSL
     DQELIKDITL TTPALISRKP IEYFEENFEE VLNNQFGEKS NSLSLMVKKS SNALVKYILD
     TQKISLTNIN DIEVYSLVDF MTIDLSSRRN LELTENLREK SKKGSLLWVL DKTETSMGSR
     MLRRWIEEPL VNKEKITLRL NAVEELFNDL SLNDSLKEAL HDIYDIERIL GKISNKNANA
     KDLIALKTSI GKIPNVKGII ENCTSSLLKN YHHNLDDLRD IYDLLEKSIK EDPSLTLKDG
     DLIKDGFNGE IDELRLAKTN GKDWISSLEN REREFTGIKS LKVGFNKVFG YYIEISKANY
     SSIPEGRYIR KQTLANAERF ITPELKEIEE KLLGASEKLC SLEYDIFLDI RNEVENHIDR
     LKTTAKIIAE LDCISNLAFV ALENDFIKPE INEDGETKIE NGRHPVVEKV IPKGEFIPND
     TIINKDDNQL LIITGPNMAG KSTYMRQVAI ITLMCQIGSF VPASKANISV VDKIFTRIGA
     SDDLAGGKST FMVEMWEVSN ILKNATENSL VLLDEVGRGT STYDGLSIAW SVIEYICKNK
     NLRCKTLFAT HYHELTKLEG EIHGVRNYSV AVKEVDNNII FLRKIIEGGA DQSYGIEVAK
     LAGIPDEVIN RAKEILETLE MESSKDNLDL ALKEVNASKE DIEEASITTS YEVKETLVEE
     DKIEIKEEVI SKASEAKTHK KEDDQIQLDF SAIGKDNLIK ELSEVDILSL NPMEAMNRLY
     ALVKEAKNLI