ID   MUTS_CLOPE              Reviewed;         909 AA.
AC   Q8XL87;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=CPE1155;
OS   Clostridium perfringens (strain 13 / Type A).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=195102;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=13 / Type A;
RX   PubMed=11792842; DOI=10.1073/pnas.022493799;
RA   Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A., Shiba T.,
RA   Ogasawara N., Hattori M., Kuhara S., Hayashi H.;
RT   "Complete genome sequence of Clostridium perfringens, an anaerobic flesh-
RT   eater.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; BA000016; BAB80861.1; -; Genomic_DNA.
DR   RefSeq; WP_011010289.1; NC_003366.1.
DR   AlphaFoldDB; Q8XL87; -.
DR   SMR; Q8XL87; -.
DR   STRING; 195102.gene:10490418; -.
DR   EnsemblBacteria; BAB80861; BAB80861; BAB80861.
DR   KEGG; cpe:CPE1155; -.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000818; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..909
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115090"
FT   BINDING         615..622
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   909 AA;  103017 MW;  07F034D4D1521EB0 CRC64;
     MKLTPMMRQY FEIKENYKDC ILFFRLGDFY EMFFEDAETA ARELELVLTG RDCGLEKRAP
     MCGIPFHASN SYIGRLVAKG YKVAICEQVE DPKVAKGIVK RDVIKVITPG TYTDSSFVEE
     TKNNYIMTIY SDLERNRCSL AITDISTGDF LATEGELEKG VILDEISKFN PKEIILLDSL
     DQELIKDITL TTPALISRKP IEYFEEKFEE VLNAQFGEKS NSLSLMVKKS SNALVKYILD
     TQKISLTNIN DIEVYSLVDF MTIDLSSRRN LELTENLREK SKKGSLLWVL DKTETSMGSR
     MLRRWIEEPL VNKEKITLRL NAVEELFNDL SLNDSLKEAL HDIYDIERIL GKISNKNANA
     KDLIALKTSI GKIPNVKGII ENCTSSLLRN YHHNLDDLRD IYELLEKSIK EDPSLTLKDG
     DLIKDGFNSE IDELRLAKTN GKDWISSLEN REREFTGIKS LKVGFNKVFG YYIEISKANY
     SSIPEGRYIR KQTLANAERF ITPELKEIEE KLLGASEKLC SLEYDIFLDI RNEVENHIDR
     LKTTAKIIAE LDCISNLAFV ALENDFIKPE INEDGETKIE NGRHPVVEKV IPKGEFIPND
     TIINKDDNQL LIITGPNMAG KSTYMRQVAI ITLMCQIGSF VPASKANISV VDKIFTRIGA
     SDDLAGGKST FMVEMWEVSN ILKNATENSL VLLDEVGRGT STYDGLSIAW SVIEYICKNK
     NLRCKTLFAT HYHELTKLEG EIHGVRNYSV AVKEVDNNII FLRKIIEGGA DQSYGIEVAK
     LAGIPDDVIN RAKEILEKLE MESSKDNLDL ALKEVNASKE EMKEASITSS YEVKETLVEE
     DKIEIKEEVI SKASEAKTHK EDDQIQLDFS AIGKDNLIKE LSEVDILSLN PMEAMNRLYA
     LVKEAKNLI