ID   MUTS_CLOPS              Reviewed;         910 AA.
AC   Q0STR4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=CPR_1171;
OS   Clostridium perfringens (strain SM101 / Type A).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=289380;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SM101 / Type A;
RX   PubMed=16825665; DOI=10.1101/gr.5238106;
RA   Myers G.S.A., Rasko D.A., Cheung J.K., Ravel J., Seshadri R., DeBoy R.T.,
RA   Ren Q., Varga J., Awad M.M., Brinkac L.M., Daugherty S.C., Haft D.H.,
RA   Dodson R.J., Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S.A.,
RA   Khouri H., Dimitrov G.I., Watkins K.L., Mulligan S., Benton J., Radune D.,
RA   Fisher D.J., Atkins H.S., Hiscox T., Jost B.H., Billington S.J.,
RA   Songer J.G., McClane B.A., Titball R.W., Rood J.I., Melville S.B.,
RA   Paulsen I.T.;
RT   "Skewed genomic variability in strains of the toxigenic bacterial pathogen,
RT   Clostridium perfringens.";
RL   Genome Res. 16:1031-1040(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000312; ABG87311.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q0STR4; -.
DR   SMR; Q0STR4; -.
DR   EnsemblBacteria; ABG87311; ABG87311; CPR_1171.
DR   KEGG; cpr:CPR_1171; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001824; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..910
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008055"
FT   BINDING         615..622
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   910 AA;  103060 MW;  F042F76CEE66DF3E CRC64;
     MALTPMMRQY FEIKENYKDC ILFFRLGDFY EMFFEDAETA ARELELVLTG RDCGLEKRAP
     MCGIPFHASN SYIGRLVAKG YKVAICEQVE DPKVAKGIVK RDVIKVITPG TYTDSSFVEE
     TKNNYIMTIY SDLERNRCSL AITDISTGDF LATEGELEKG VILDEISKFN PKEIILLDSL
     DQELIKDITL TTPALISRKP IEYFEEKFEE VLNSQFGEKS NSLSLMIKKS SNALVKYILD
     TQKISLTNIN DIEVYSLVDF MTIDLSSRRN LELTENLREK SKKGSLLWVL DKTETSMGSR
     MLRRWIEEPL VNKEKITLRL NAVEELFNDL SLNDSLKEAL HDIYDIERIL GKISNKNANA
     KDLIALKTSI GKIPNVKGII ENCTSSLLKN YHHNLDDLRD IYELLEKSIK EDPSLTLKDG
     DLIKDGFNGE IDELRLAKTN GKDWISSLEN REREFTGIKS LKVGFNKVFG YYIEISKANY
     SSIPEGRYIR KQTLANAERF ITPELKEIEE KLLGASEKLC SLEYDIFLDI RNEVENHIDR
     LKTTAKIIAE LDCISNLAFV ALENDFIKPE INEDGETKIE NGRHPVVEKV IPKGEFIPND
     TIINKDDNQL LIITGPNMAG KSTYMRQVAI ITLMCQIGSF VPASKANISV VDKIFTRIGA
     SDDLAGGKST FMVEMWEVSN ILKNATENSL VLLDEVGRGT STYDGLSIAW SVIEYICKNK
     NLRCKTLFAT HYHELTKLEG EIHGVRNYSV AVKEVDNNII FLRKIIEGGA DQSYGIEVAK
     LAGIPDEVIN RAKEILETLE MESSKDNLDL ALKEVNASKE EMKEASIEAS YEVKETIVEE
     DKIEIIEEII SKSSDAKTHK KEDDQIQLDF SAIGKDNLIK ELSEVDILSL NPMEAMNRLY
     ALVKEAKNLI