ID   MUTS_CLOTE              Reviewed;         881 AA.
AC   Q895H2;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=CTC_01302;
OS   Clostridium tetani (strain Massachusetts / E88).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=212717;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Massachusetts / E88;
RX   PubMed=12552129; DOI=10.1073/pnas.0335853100;
RA   Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H.,
RA   Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A.,
RA   Gottschalk G.;
RT   "The genome sequence of Clostridium tetani, the causative agent of tetanus
RT   disease.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AE015927; AAO35868.1; -; Genomic_DNA.
DR   RefSeq; WP_011099530.1; NC_004557.1.
DR   AlphaFoldDB; Q895H2; -.
DR   SMR; Q895H2; -.
DR   STRING; 212717.CTC_01302; -.
DR   EnsemblBacteria; AAO35868; AAO35868; CTC_01302.
DR   GeneID; 64179096; -.
DR   KEGG; ctc:CTC_01302; -.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001412; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..881
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115091"
FT   BINDING         612..619
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   881 AA;  100220 MW;  5E3B91DEEC58B810 CRC64;
     MKLTPMMQQY LEVKEKCKDC ILFFRLGDFY EMFFEDAETA SKELELVLTG RDCGLSKRAP
     MCGIPYHSAS NYINRLVSKG YKIAICEQLE DPSAAKGIVK RDIVKIVTPG TYSDSNFLNE
     TKNNYIMSLY IEDKSVAMCF CDISTGDFFA TSHSLDKSII LDEISKFDPS ELLLNKDIDK
     NILKEIKNRF TISITNLEKD YFKDYNLLEG QFSDFSKEEY SLVLIKCGNG LLKYILETQK
     MSLGHIDCFK NYNIVDYLSM DINSRRNLEI TETIRDKSRK GSLLWVLDKC STAMGARLIR
     NWVEQPLINK EKIDKRLNAV EELVLNISLH EDLKDALKDI YDIQRIVGKI SSKNVNAKEL
     LSLKNSIEKL PYIKDILSKL EADLFKDMLS NLDELKDIYE LLESSIMDNP PITIKDGNLI
     KNGFNKEIDE LRMAKSHGKE WIANLESSER EFTGIKSLKV GYNKVFGYFI EVTKSNISSV
     PEGRYVRKQT LSNCERYITP ELKEMEDKIL GAEEKLISLE YEVFVSIRNS IEKDIDRMKI
     SANIVAILDC LSSLSTVALE NNYSKPKILE GNDIIIKDGR HPVVEKMIPT GSFVANDTTM
     DTEDNQMLLI TGPNMAGKST YMRQVALITI MAQIGSFVPA KEASISLCDK IFTRIGASDD
     LSAGKSTFMV EMWEVSNILK NATSKSLIIL DEVGRGTSTF DGLSIAWAVI EYICNNKNLR
     SKTLFATHYH ELIQLENKIK GVKNYSVSVK EMDKDIVFLR KIIEGGADQS YGIEVAKLAG
     LPEDVIIRAK EILNSIEQNK DNKIELDDIK ENKNHIEKEN KKEIATDKLL ANDDFQISFT
     QIEEENLIKE ISSIDILNLN PMEGFNKLYD LINKAKSIEK K