ID   MUTS_COLP3              Reviewed;         872 AA.
AC   Q47WN0;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=CPS_4137;
OS   Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio
OS   psychroerythus).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Colwelliaceae; Colwellia.
OX   NCBI_TaxID=167879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=34H / ATCC BAA-681;
RX   PubMed=16043709; DOI=10.1073/pnas.0504766102;
RA   Methe B.A., Nelson K.E., Deming J.W., Momen B., Melamud E., Zhang X.,
RA   Moult J., Madupu R., Nelson W.C., Dodson R.J., Brinkac L.M.,
RA   Daugherty S.C., Durkin A.S., DeBoy R.T., Kolonay J.F., Sullivan S.A.,
RA   Zhou L., Davidsen T.M., Wu M., Huston A.L., Lewis M., Weaver B.,
RA   Weidman J.F., Khouri H., Utterback T.R., Feldblyum T.V., Fraser C.M.;
RT   "The psychrophilic lifestyle as revealed by the genome sequence of
RT   Colwellia psychrerythraea 34H through genomic and proteomic analyses.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:10913-10918(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000083; AAZ28408.1; -; Genomic_DNA.
DR   RefSeq; WP_011044873.1; NC_003910.7.
DR   AlphaFoldDB; Q47WN0; -.
DR   SMR; Q47WN0; -.
DR   STRING; 167879.CPS_4137; -.
DR   PRIDE; Q47WN0; -.
DR   EnsemblBacteria; AAZ28408; AAZ28408; CPS_4137.
DR   KEGG; cps:CPS_4137; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000547; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..872
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224363"
FT   BINDING         632..639
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   872 AA;  96274 MW;  817423F27B81B2A0 CRC64;
     MTTATKDLSS HTPMMRQYLT IKAEFPHTLI FYRMGDFYEL FFDDAKKASD LLDISLTARG
     KTGGNAIPMA GVPYHAAENY LAKLVALGES VAICEQIGDP ATSKGPVERK VVRVITPGTV
     SDEALLVDRQ DNLIVAIVDN QSPNAKLKTS SAPAFGLAYL DMASGRFVLT EPQTAEQLQA
     ELQRLSPAEL LYSESLQDFS LIEQRKGLRR RPEWEFDLDT AISLLNKQFD TKELTGFGVD
     DKPLGLAAAG CLFQYVKDTQ RTALPHIRAI VCESANKGVV LDAATRRNLE LTQNLHGGLD
     NTLAAILDKS STPMGSRLLK RWLHFPLRDL TVLNNRQNTV SDIIALDLIA PIQPLLKGLG
     DIERIVSRIA LGSARPRDFA RLRHALQQLP ELQNELKSGL TESPTNYLAT IAQQSQPMPQ
     LEGLLVHAIV ENPPVLIRDG GVIAPGYNNE LDVLRDLSDG ATEFLAQLEQ REKERTGIHS
     LKVGYNRVHG FFIEMSRTAA VDVPDDYIRR QTLKNNERFI TEELKQHEEK VLSAQSKFLA
     LEKSLYQELF DKVLPDLAQL QQLSQAIAEL DVLTTFAERA LALNYVKPSL VEEPGISIDA
     GRHVVVEQMT NDAFIANPVL LTEQRKMLII TGPNMGGKST YMRQTALIVL LAHIGCYVPA
     DNATIGLVDR IFTRIGASDD LASGRSTFMV EMTETANILH NATDKSLVLL DEIGRGTSTY
     DGLSLAWACA EMLALKTKAF TLFATHYFEL TLLAGQISTL ANVHLDAMEH DDNIVFMHAV
     QEGAASKSFG LQVAQLAGVP KTVIKRAKQR LSELEQQQTP SILPAPIQND AFEQLSFAPE
     EHSVVTTLID TDINELSPRQ ALDLLFSLKE QL