ID   MUTS_COXBN              Reviewed;         859 AA.
AC   A9KG24;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=CBUD_0986;
OS   Coxiella burnetii (strain Dugway 5J108-111).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales; Coxiellaceae;
OC   Coxiella.
OX   NCBI_TaxID=434922;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Dugway 5J108-111;
RX   PubMed=19047403; DOI=10.1128/iai.01141-08;
RA   Beare P.A., Unsworth N., Andoh M., Voth D.E., Omsland A., Gilk S.D.,
RA   Williams K.P., Sobral B.W., Kupko J.J. III, Porcella S.F., Samuel J.E.,
RA   Heinzen R.A.;
RT   "Comparative genomics reveal extensive transposon-mediated genomic
RT   plasticity and diversity among potential effector proteins within the genus
RT   Coxiella.";
RL   Infect. Immun. 77:642-656(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABS76827.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000733; ABS76827.2; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; A9KG24; -.
DR   SMR; A9KG24; -.
DR   EnsemblBacteria; ABS76827; ABS76827; CBUD_0986.
DR   KEGG; cbd:CBUD_0986; -.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000008555; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..859
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335144"
FT   BINDING         622..629
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   859 AA;  97319 MW;  4523AB2892EF1D41 CRC64;
     MELQTKSPTT QNDFSQHTPM MRQYLRIKAE YPDLLVFYRM GDFYELFYDD AKKAAKLLNI
     TLTARGQSAG HAIPMAGVPY HAVENYLTKL VRLGESVVIC EQIGDPATSK GPVAREVTRI
     ITPGTVSDEA LLDEHRDNTL MVIHQEKDRF GIATLDITSG RFLIQEIISE NALFAEIERI
     RPAELLISEE NSVHPLKADS IKRRPPWEFD HATALTLLCQ QFQTKSLDGF GITHLPLAIT
     AAGCLLQYVN YTQKSALPHI HSIQAEQNEE ALFIDANTRR NLELITNLQG EEVHSLAWLL
     DHTATPMGSR LLRRWINRPL RDQILLQQRQ NAVSTLLEKR NYSEIYENLR HIGDLERIVA
     RIALRSARPR DLMQLRQALG VLPTLHQQLT NLPLNKQLQE IKNNLGLFDE LFRLLQKAII
     ENPPIVIRDG GVIADGYDAP LDELRNMSTN SHQFLIDLEQ QERERTKINT LKVGYNRIHG
     YYIEISRAQA KQAPTEYIRR QTLKNVERYI TPELKIFEDK VLSSRSRALA REKELYEQLL
     DTLIEKLIPL QQCASAIANL DVLNTLAERA DTLNFNAPQF CDYPIIKIEA GRHPIVENVM
     TDPFMPNDTH LDEKRRMLII TGPNMGGKST YMRQTALITL LAYIGSFVPA KNAQLGPIDR
     IFTRIGAADD LASGRSTFMV EMTETAAILH NATEESLVLM DEVGRGTSTF DGLSLAYACA
     SYLATKLKAF ALFATHYFEL TALASTLPAV KNVHLDAVEH EEKIIFLHAL REGPANKSYG
     LQVAQLAGIP RSVIQHARQK LEELENPVIS ETQQPQQNEL FLPIENPVLT QLDKLNPDNL
     TPKQALDILY QLIQLRQQK