ID   MUTS_COXBU              Reviewed;         859 AA.
AC   Q83CQ2;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=CBU_1056;
OS   Coxiella burnetii (strain RSA 493 / Nine Mile phase I).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales; Coxiellaceae;
OC   Coxiella.
OX   NCBI_TaxID=227377;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RSA 493 / Nine Mile phase I;
RX   PubMed=12704232; DOI=10.1073/pnas.0931379100;
RA   Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C.,
RA   Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T.,
RA   Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M.,
RA   Lee K.H., Carty H.A., Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E.,
RA   Fraser C.M., Heidelberg J.F.;
RT   "Complete genome sequence of the Q-fever pathogen, Coxiella burnetii.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAO90571.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE016828; AAO90571.2; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_820057.2; NC_002971.3.
DR   AlphaFoldDB; Q83CQ2; -.
DR   SMR; Q83CQ2; -.
DR   STRING; 227377.CBU_1056; -.
DR   EnsemblBacteria; AAO90571; AAO90571; CBU_1056.
DR   GeneID; 1208957; -.
DR   KEGG; cbu:CBU_1056; -.
DR   PATRIC; fig|227377.7.peg.1047; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000002671; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..859
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115092"
FT   BINDING         622..629
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   859 AA;  97336 MW;  40FAFFFCDAD2166F CRC64;
     MELQTKSPTT QNDFSQHTPM MRQYLRIKAE YPDLLVFYRM GDFYELFYDD AKKAAKLLNI
     TLTARGQSAG HAIPMAGVPY HAVENYLTKL VRLGESVVIC EQIGDPATSK GPVAREVTRI
     ITPGTVSDEA LLDEHRDNTL MVIHQEKDRF GIATLDITSG RFLIQEIISE NALFAEIERI
     RPAELLISEE NSVHPLKADS IKRRPPWEFD HATALTLLCQ QFQTKSLDGF GITHLPLAIT
     AAGCLLQYVN YTQKSALPHI HSIQAEQNEE ALFIDANTRR NLELITNLQG EEVHSLAWLL
     DHTATPMGSR LLRRWINRPL RDQILLQQRQ NAVSTLLEKR NYSEIYENLR HIGDLERIVA
     RIALRSARPR DLMQLRQALG VLPTLHQQLT NLPLNKQLQE IKNNLGLFDE LFRLLKKAII
     ENPPIVIRDG GVIADGYDAP LDELRNMSTN SHQFLIDLEQ QERERTKINT VKVGYNRIHG
     YYIEISRAQA KQAPTEYIRR QTLKNVERYI TPELKIFEDK VLSSRSRALA REKELYEQLL
     DTLIEKLIPL QQCASAIANL DVLNTLAERA DTLNFNAPQF CDYPIIKIEA GRHPIVENVM
     TDPFMPNDTH LDEKRRMLII TGPNMGGKST YMRQTALITL LAYIGSFVPA KNAQLGPIDR
     IFTRIGAADD LASGRSTFMV EMTETAAILH NATEESLVLM DEVGRGTSTF DGLSLAYACA
     SYLATKLKAF ALFATHYFEL TALASTLQAV KNVHLDAVEH EEKIIFLHAL REGPANKSYG
     LQVAQLAGIP RSVIQHARQK LEELENPVIS ETQQPQQNEL FLPIENPVLT QLDKLNPDNL
     TPKQALDILY QLIQLRQQK