ID   MUTS_CROS8              Reviewed;         853 AA.
AC   A7MJ43;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=ESA_00558;
OS   Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Cronobacter.
OX   NCBI_TaxID=290339;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-894;
RX   PubMed=20221447; DOI=10.1371/journal.pone.0009556;
RA   Kucerova E., Clifton S.W., Xia X.Q., Long F., Porwollik S., Fulton L.,
RA   Fronick C., Minx P., Kyung K., Warren W., Fulton R., Feng D., Wollam A.,
RA   Shah N., Bhonagiri V., Nash W.E., Hallsworth-Pepin K., Wilson R.K.,
RA   McClelland M., Forsythe S.J.;
RT   "Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic
RT   hybridization analysis with other Cronobacter species.";
RL   PLoS ONE 5:E9556-E9556(2010).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000783; ABU75848.1; -; Genomic_DNA.
DR   RefSeq; WP_012123940.1; NC_009778.1.
DR   AlphaFoldDB; A7MJ43; -.
DR   SMR; A7MJ43; -.
DR   EnsemblBacteria; ABU75848; ABU75848; ESA_00558.
DR   KEGG; esa:ESA_00558; -.
DR   PATRIC; fig|290339.8.peg.503; -.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000260; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..853
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000071276"
FT   BINDING         614..621
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   853 AA;  95092 MW;  6AD08497B0FE547F CRC64;
     MSTSETFDAH TPMMQQYLKL KAQHPDILLF YRMGDFYELF YDDAKRASQL LDISLTKRGA
     SAGEPIPMAG VPHHAVENYL AKLVNLGESV AICEQIGDPA TSKGPVERKV VRIVTPGTIS
     DEALLQERQD NLLAAIWQDS KGFGYATLDI SSGRFRVSEP QDRETMAAEL QRTNPAELLY
     AEDFAEMSLI EGRRGLRRRP LWEFELDTAR QQLNLQFGTR DLVGFGVENA PRGLCAAGCL
     LQYVKDTQRT SLPHIRSITM ERQQDGIIMD AATRRNLEIT QNLAGGVENT LASVLDCTVT
     PMGSRMLKRW LHMPVRDTSV LRHRQQAIAA LMEYSTEIQP VLRQVGDLER ILARLALRTA
     RPRDLARMRH AFQQLPTLNT LLADIEAEYV QTLREQMGDF AELRDLLERA IIEAPPVLVR
     DGGVIAPGYH EELDEWRALA DGATDYLDRL EIREREKLGI DTLKVGFNAV HGYFIQVSRG
     QSHMVPIHYV RRQTLKNAER YIIPELKEYE DKVLTSKGKA LALEKQLYDE LFDLLLPHLA
     ELQKSAAALA ELDVLTNLAE RADTLNYHCP TLTDKPGIRL VEGRHPVVER VLNEPFIANP
     LSLSPQRRML IITGPNMGGK STYMRQTALI VLMAYIGSFV PAEQAEIGPI DRIFTRVGAA
     DDLASGRSTF MVEMTETANI LHNATEHSLV LMDEIGRGTS TYDGLSLAWA CAESLANRIK
     ALTLFATHYF ELTQLPEKME GVANVHLDAI EHGDTIAFMH SVQDGAASKS YGLAVAALAG
     VPKEVIKRAR QKLRELESLS GNAAATQVDG TQMSLLAAAE ETSPAVEALE NLDPDSLSPR
     QALEWIYRLK SLV