ID   MUTS_CUPMC              Reviewed;         916 AA.
AC   Q1LPG5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Rmet_1075;
OS   Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 /
OS   CH34) (Ralstonia metallidurans).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=266264;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43123 / DSM 2839 / NBRC 102507 / CH34;
RX   PubMed=20463976; DOI=10.1371/journal.pone.0010433;
RA   Janssen P.J., Van Houdt R., Moors H., Monsieurs P., Morin N., Michaux A.,
RA   Benotmane M.A., Leys N., Vallaeys T., Lapidus A., Monchy S., Medigue C.,
RA   Taghavi S., McCorkle S., Dunn J., van der Lelie D., Mergeay M.;
RT   "The complete genome sequence of Cupriavidus metallidurans strain CH34, a
RT   master survivalist in harsh and anthropogenic environments.";
RL   PLoS ONE 5:E10433-E10433(2010).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000352; ABF07961.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q1LPG5; -.
DR   SMR; Q1LPG5; -.
DR   STRING; 266264.Rmet_1075; -.
DR   EnsemblBacteria; ABF07961; ABF07961; Rmet_1075.
DR   KEGG; rme:Rmet_1075; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_4; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000002429; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..916
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335209"
FT   REGION          1..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          843..880
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        843..860
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         656..663
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   916 AA;  99842 MW;  542A42985B7D2A44 CRC64;
     MSEALSVPAA EGENTVTASE SPDLAATSAR AEKVGKQEKP EKAEKQSPMM LQYHRIKADH
     PDTLLFYRMG DFYELFHDDA EKAARLLDIT LTARGQSGGV PIRMAGIPFH SADQYLARLV
     KLGESVAICE QIGDPATSKG PVERKVVRIV TPGTLTDAAL LPDKSDTFLL AVHQQTTRRG
     VSKTGLAWLN LASGELRLME CDAAQLSREL ERIRPAEVLY TDGMDLPTLT CARTRLPEWH
     FDQEAGTRRL REQIGVASLE PFGCSGLGAA LGAAGALLNY AATTQGQSLR HVQGVTVERE
     SEFVGLDSAT RRNLELTETL RGTESPTLFS LLDTCATTMG SRALRHWLHH PLRDPALPRA
     RQQAIGALIT QGPDGLRAVL RKLADVERIT ARLALLSARP RDLSSLRDTL RALPDVQAAT
     VSSEDAPLLA QTLEEIDIPQ DCLELLIRAV ADEPSTVIRD GGVIARGYDS ELDELRDISE
     NCGQFLIDLE TRERERTGIT NLRVEYNRVH GFYIEVTNGQ ADKVPDDYRR RQTLKNAERY
     ITPELKAFED KALSAQDRAL AREKQLYDGL LQALLPHIGS LRRVAGALAR LDVLATLAER
     AKTLDWVQPE RVQENVIDIS QGRHPVVEGQ LAAESVAFIA NDCQLNEARK LLLITGPNMG
     GKSTFMRQTA LIVLLACVGA WVPARRAVIG PVDRIFTRIG AADDLAGGRS TFMVEMTEAA
     AILHNATPSS LVLMDEIGRG TSTFDGLALA WAIARHLLSH NRSHTLFATH YFELTQLPVE
     FPQAANVHLS AVEHGDGIVF LHAVQDGPAS QSYGLQVAQL AGVPQPVIRA ARKHLAWLEE
     QSADATPTPQ MDLFSAQSSP SADDEDDKSA GQSAVPPAQA ATLEALADID PDSLSPREAL
     EALYRLKSIS ETARTV