ID   MUTS_CUPNH              Reviewed;         899 AA.
AC   Q0KCC0;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=H16_A1210;
OS   Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442
OS   / H16 / Stanier 337) (Ralstonia eutropha).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=381666;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337;
RX   PubMed=16964242; DOI=10.1038/nbt1244;
RA   Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R.,
RA   Eitinger T., Ewering C., Poetter M., Schwartz E., Strittmatter A., Voss I.,
RA   Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.;
RT   "Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia
RT   eutropha H16.";
RL   Nat. Biotechnol. 24:1257-1262(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AM260479; CAJ92351.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q0KCC0; -.
DR   SMR; Q0KCC0; -.
DR   STRING; 381666.H16_A1210; -.
DR   EnsemblBacteria; CAJ92351; CAJ92351; H16_A1210.
DR   KEGG; reh:H16_A1210; -.
DR   PATRIC; fig|381666.6.peg.1599; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_1_4; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000008210; Chromosome 1.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..899
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335208"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          832..852
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         631..638
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   899 AA;  97586 MW;  BC27CBA733DEA729 CRC64;
     MGLQKKTDPE QAQADSAASR HTPMMQQYLR IKADHPDTLL FYRMGDFYEL FHDDAEKAAR
     LLDITLTARG ASNGVPIRMA GIPFHSADQY LARLVKLGES VAICEQIGDP ATSKGPVERK
     VVRIVTPGTL TDAALLPDKA DTFLMAVHQQ TTRRGVSKTG LAWLNLASGE LRLMECEAAQ
     LGRELERIRP AELLYADGIE LPALACARTR LPEWHFDQDA GTRRLREQLG VASLDPFGCA
     GLGAALGAAG ALLNYAATTQ GQSLRHVQGV KVERESEYVG LDSATRRNLE LTETLRGGES
     PTLFSLLDTC CTAMGSRALR HWLHHPLRDP ALPQARQQAI GVLIDQGTDA LRTALRRLAD
     VERITSRLAL LNARPRDLSS LRDTLRALPD VQACIRDDQG STLLAQSLHD LAVPQDCLDL
     LVRAVAEEPA TVVRDGGVIA RGYDAGLDEL RDISENCGQF LIDLETRERA RTGIANLRVE
     FNRVHGFYIE VTNGQADKVP DDYRRRQTLK NAERYITPEL KAFEDKALSA QDRALAREKQ
     LYDGLLQALL PHIGELQRVA GALARLDVLT ALAERAQTLD WSAPERVAEN VVDIVQGRHP
     VVEGQLAAES VAFIANDCQL NEARKLLLIT GPNMGGKSTF MRQTALIVLL ACVGAYVPAR
     RAVIGPIDRI FTRIGAADDL AGGRSTFMVE MTEAAGILHH ATPASLVLMD EIGRGTSTFD
     GLALAWAIAR HLLSHNRSHT LFATHYFELT QLPQEFPQAA NVHLSAVEHG DGIVFLHAVQ
     DGPASQSYGL QVAQLAGVPQ PVIRAARKHL AWLEQQSADA TPTPQLDLFA APPTPDDDED
     DFGAAPSAVP APLAPTLAPE QAALVDALAN LDPDTLTPRA ALEALYRLKA LAGEALDAA