ID   MUTS_CUPPJ              Reviewed;         894 AA.
AC   Q473E4;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 2.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Reut_A1111;
OS   Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Cupriavidus necator
OS   (strain JMP 134)).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=264198;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JMP134 / LMG 1197;
RX   PubMed=20339589; DOI=10.1371/journal.pone.0009729;
RA   Lykidis A., Perez-Pantoja D., Ledger T., Mavromatis K., Anderson I.J.,
RA   Ivanova N.N., Hooper S.D., Lapidus A., Lucas S., Gonzalez B.,
RA   Kyrpides N.C.;
RT   "The complete multipartite genome sequence of Cupriavidus necator JMP134, a
RT   versatile pollutant degrader.";
RL   PLoS ONE 5:E9729-E9729(2010).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAZ60489.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000090; AAZ60489.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; Q473E4; -.
DR   SMR; Q473E4; -.
DR   STRING; 264198.Reut_A1111; -.
DR   PRIDE; Q473E4; -.
DR   EnsemblBacteria; AAZ60489; AAZ60489; Reut_A1111.
DR   KEGG; reu:Reut_A1111; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_4; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..894
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224397"
FT   REGION          819..840
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         629..636
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   894 AA;  97562 MW;  8FFA6FC5BC549AF2 CRC64;
     MQEKIELNQE VAKPLAEKHT PMMQQYLRIK ADHPDTLLFY RMGDFYELFH DDAEKAARLL
     DITLTARGSS NGVPIRMAGI PFHSADQYLA KLVKLGESVA ICEQIGDPAA SKGPVERKVV
     RIVTPGTLTD ASLLPDKSDT FLMAVHQQTT RRGVSKTGLA WLNLASGELR LMECEAAQLA
     REFERIRPAE LLYADGIDLP AVACARTRLP EWHFDQDAGT RRLLEQLGVA SLEPFGCAGL
     GAAIGAAGAL LNYAATTQGQ SLRHVRDIKV ERESEFVGLD SATRRNLELT ETLRGGESPT
     LFSLLDTCAT AMGSRALRHW LHHPLRDPAL PRARQQAIGV LIDHGIDDLR SALRKLADVE
     RITSRLALLS ARPRDLSSLR DTLRALPHVR ACLQAEPDSS LLSLTVAELA VPQACLDLLI
     SAVAEEPATV VRDGGVIARG YDAELDELRD ISENCGQFLV DLESRERTRT GIANLRVEYN
     RVHGFYIEVT NGQADKVPDD YRRRQTLKNA ERYITPELKA FEDKALSAQD RALAREKQLY
     DVLLQALLPH IGELQRVAGA LARLDVLASL AERAQTLDWS CPERVGDNVI DIVQGRHPVV
     EGQLAAESVP FIANDCQLNE ARKLLLITGP NMGGKSTFMR QTALIVLLAC VGAYVPARRA
     VIGPVDRIFT RIGAADDLAG GRSTFMVEMT EAAAILHHAT PASLVLMDEI GRGTSTFDGL
     ALAWAIARHL LSHNRSHTLF ATHYFELTQL PQEFPQAANV HLSAVEHGDG IVFLHAVQDG
     PASQSYGLQV AQLAGVPQPV IRAARKHLAW LEQQSADATP TPQLDLFAPP PHPDTSDDDE
     PVSIGKPVQV ALLPEQAAVL DALSDLDPDS LTPRAALDAL YRLKVLAGEV VDAA