ID   MUTS_CYTH3              Reviewed;         856 AA.
AC   Q11YS6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=CHU_0147;
OS   Cytophaga hutchinsonii (strain ATCC 33406 / DSM 1761 / CIP 103989 / NBRC
OS   15051 / NCIMB 9469 / D465).
OC   Bacteria; Bacteroidetes; Cytophagia; Cytophagales; Cytophagaceae;
OC   Cytophaga.
OX   NCBI_TaxID=269798;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33406 / DSM 1761 / CIP 103989 / NBRC 15051 / NCIMB 9469 / D465;
RX   PubMed=17400776; DOI=10.1128/aem.00225-07;
RA   Xie G., Bruce D.C., Challacombe J.F., Chertkov O., Detter J.C., Gilna P.,
RA   Han C.S., Lucas S., Misra M., Myers G.L., Richardson P., Tapia R.,
RA   Thayer N., Thompson L.S., Brettin T.S., Henrissat B., Wilson D.B.,
RA   McBride M.J.;
RT   "Genome sequence of the cellulolytic gliding bacterium Cytophaga
RT   hutchinsonii.";
RL   Appl. Environ. Microbiol. 73:3536-3546(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000383; ABG57440.1; -; Genomic_DNA.
DR   RefSeq; WP_011583556.1; NC_008255.1.
DR   AlphaFoldDB; Q11YS6; -.
DR   SMR; Q11YS6; -.
DR   STRING; 269798.CHU_0147; -.
DR   EnsemblBacteria; ABG57440; ABG57440; CHU_0147.
DR   KEGG; chu:CHU_0147; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_10; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001822; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..856
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335146"
FT   BINDING         607..614
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   856 AA;  96792 MW;  AEE226799D75646E CRC64;
     MKQYNAIKGK YPGALLLFRV GDFYETFSED AIKASKVLGI TLTKRGNGTA SETALAGFPH
     HSLDTYLPRL VRSGLRVAIC DQLEDPKSVK GIVKRGVTEL VTPGVSFNDH VLDVSKNNYL
     AAIHFQKDSL GISFLDISTG EFLTAQGDRH YIDKLLQSFS PSEVLFCKQK KEVFIEYFGD
     RYNTYALEDW IFAYDFTYDL LIRHFQTTSL KGFGIEEMLE GITSAGAILH YLNETEHKEV
     AHITRVNRIE EERYVWLDRF TIRNLELVNA QQLEGVPLIE ILDHTKTPMG ARLLKKWLIL
     PLKELTPIQE RLDTVELLVK NKELTTTLVD ELKPIGDLER LISKVAARRV NPREMVQLKR
     SLERLVPIQQ LLKQQDQHVL LKLAEQINPC EYLAGRILNM LKEDAPMLTN QGRIIRDGCN
     AELDELRAIA YTGKDYLLQI QQREIERTGI SSLKISYNKV FGYYLEVTNT HKEKVPADWI
     RKQTLTGAER YITEELKIYE EKILGAEDKI NVIEQKMFQD LVLEAESYIN PILQNARIVA
     QIDCLCSFAH AAVANNYCKP IVEDSALINI KAGRHPVIEK QLPLGESYIP NDIYLDDETQ
     QVMIITGPNM AGKSALLRQT ALIVLMAQAG SFVPATHATI GTVDKVFTRV GASDNLSKGE
     STFMVEMNET ASILNNLSGR SLVLMDEIGR GTSTYDGISI AWAIVEHLHN HPNFRPKTLF
     ATHYHELNQL TEDLKRVKNF NVSVKEAGNK VIFMRTLKPG GSEHSFGIHV AQMAGMPTSL
     VLRANEIMGH LEKEHVREGH EDKLKEVPKS TLQMSLFEAA DPAWDSIKKI LTQTDVNIMS
     PVEALLKLNE LKQLIK