ID   MUTS_DECAR              Reviewed;         860 AA.
AC   Q47DJ8;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Daro_2347;
OS   Dechloromonas aromatica (strain RCB).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Rhodocyclales; Azonexaceae;
OC   Dechloromonas.
OX   NCBI_TaxID=159087;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RCB;
RX   PubMed=19650930; DOI=10.1186/1471-2164-10-351;
RA   Salinero K.K., Keller K., Feil W.S., Feil H., Trong S., Di Bartolo G.,
RA   Lapidus A.;
RT   "Metabolic analysis of the soil microbe Dechloromonas aromatica str. RCB:
RT   indications of a surprisingly complex life-style and cryptic anaerobic
RT   pathways for aromatic degradation.";
RL   BMC Genomics 10:351-351(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000089; AAZ47083.1; -; Genomic_DNA.
DR   RefSeq; WP_011288082.1; NC_007298.1.
DR   AlphaFoldDB; Q47DJ8; -.
DR   SMR; Q47DJ8; -.
DR   STRING; 159087.Daro_2347; -.
DR   EnsemblBacteria; AAZ47083; AAZ47083; Daro_2347.
DR   KEGG; dar:Daro_2347; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_4; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..860
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224364"
FT   BINDING         620..627
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   860 AA;  94565 MW;  C49A830E543D33F9 CRC64;
     MVKDKAPDLS KHTPMMRQYL ALKANHPNTL LFYRMGDFYE LFHEDAEKAA RLLDITLTTR
     GQSAGVPIKM CGIPFHSLEP YLARLVKLGE SAVICEQIGD PATSKGPVER AVARIVTPGT
     LTDAALIDDK QDLWLLAVTT HRNTAGIARL NLASGEFILI EVPTEQIPAT LERIRPAEIL
     YPESWTPNFG VDVARTRQPD WYFEFDSARR LLCDQFEVAS LAGFGAEGLK PAIAAAGALL
     QYAQATQSGK LPHLRGLTVE IEGAYLGLDL ATRRNLELTE TLRGQPSPTL FSLLDNCVTS
     MGSRLLRHTL HHPLRARDIP AARHGAVEAL LEDYGRLGNE VRKALRGIAD IERIAGRVAL
     RNARPRDLAS LRESVARLEG LRAPLSDSPA PLIAQLFTEL ETPYPALELL VRAIAAEPGA
     QVRDGGVIAP GYDPDLDELR SLNDNCGAFL VDMEARERER SGIASLKVEY NKVHGFYIEV
     THANVDKIPD DYRRRQTLKN AERYITPELK AFEDKALSAQ ERSLAREKLL YEAILDALLP
     VVPTLQTIAR AIAQLDLLAG FAESALKRNW CKPEFAAETQ LSITGGRHPV VEGELTNQAE
     TFIANDCLLA ENRRLLLITG PNMGGKSTYM RQVALIALLA HIGCYVPADR CVLGPLDRIF
     TRIGASDDLA SGRSTFMVEM TEAAAILHHA TNQSLVLMDE IGRGTSTFDG MALAFAILRH
     LIEKNQSLTL FATHYFELTR LSHEYSELAN VHLGAVEHND RIVFMHAVEE GPANQSYGIQ
     VAALAGIPTA VVRAARKQLR EFEQRAAVDP LQPDLFAQGA PEPAEPEPHP VVEQLAAIDP
     DSLTPREALD ALYALKGLLR