ID   MUTS_DEHM1              Reviewed;         858 AA.
AC   Q3Z767;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=DET1219;
OS   Dehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195)
OS   (Dehalococcoides ethenogenes (strain 195)).
OC   Bacteria; Chloroflexi; Dehalococcoidia; Dehalococcoidales;
OC   Dehalococcoidaceae; Dehalococcoides.
OX   NCBI_TaxID=243164;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-2266 / KCTC 15142 / 195;
RX   PubMed=15637277; DOI=10.1126/science.1102226;
RA   Seshadri R., Adrian L., Fouts D.E., Eisen J.A., Phillippy A.M., Methe B.A.,
RA   Ward N.L., Nelson W.C., DeBoy R.T., Khouri H.M., Kolonay J.F., Dodson R.J.,
RA   Daugherty S.C., Brinkac L.M., Sullivan S.A., Madupu R., Nelson K.E.,
RA   Kang K.H., Impraim M., Tran K., Robinson J.M., Forberger H.A., Fraser C.M.,
RA   Zinder S.H., Heidelberg J.F.;
RT   "Genome sequence of the PCE-dechlorinating bacterium Dehalococcoides
RT   ethenogenes.";
RL   Science 307:105-108(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000027; AAW39511.1; -; Genomic_DNA.
DR   RefSeq; WP_010936909.1; NC_002936.3.
DR   AlphaFoldDB; Q3Z767; -.
DR   SMR; Q3Z767; -.
DR   STRING; 243164.DET1219; -.
DR   EnsemblBacteria; AAW39511; AAW39511; DET1219.
DR   KEGG; det:DET1219; -.
DR   PATRIC; fig|243164.10.peg.1152; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_0; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000008289; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..858
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224365"
FT   BINDING         613..620
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   858 AA;  95361 MW;  EFC2348C91B1C7DD CRC64;
     MENITPLRKQ YLDIKKNYPE AIVFFRLGDF YETFEEDARI AARELEIVLT SREMGKGLKV
     PLAGIPYHAL DNYLSRLINR GYKVAICEQV TKPGETKGLV KRQVTRLVTP GTVVEPNLLD
     SKQNNFLLSL YLTEDSCGLA FADISTSEFG CTQLDINGLE AEINRLNPAE IILPKSQSLN
     LPLHLKATIS KLDGYYFEAD VARERLLKHF ECQNLSAYGC ENLPLAVSAA GALLNYLEET
     QKSSLKQLER LAAYTISDYM QIDSHTLSNL EIFRSSGGNS LKGSLLGVLD QTKTAMGGRL
     LRKFLGQPLL RQEDIEKRLS AVDYFFEESL ARASLAKALG QIADMERIAN RIRQKTILPK
     ELISLKNSLE TVSAIHRQFG LMPPPRLAYF LNGLKPLPEM LDIVNEAIND DPPSTLGEGK
     VIRSGFNPEM DKLCSLAGDA RTFLSQMEAR EREQTGIKSL KLGYNRVFGY YIEVSNANLA
     DIPQNYIRKQ TLVNAERFIT PELKEYENLI LNAKERLLEM ETGLYEQVLN QLGGFYSALL
     SNAAALASLD VLSAFAEVAV RNGYVRPLFH SENSLVIHRG RHPMVEQGLG YGSFAANDIS
     LSAEDCQIII LTGPNMAGKS TYLKQTALIV LMAQIGSYVP AETAELCLTD RIFSRIGARE
     DLSAGQSTFM VEMVETASIL NTATSRSLLI LDEIGRGTST YDGLAIAQAV VEYIHSQPSL
     HAKTLFATHY HELVELANYL PRVKNYNIAV SEDRGEVVFL HRIVPGGVDK SYGIHVAKLA
     GLPGWVIKRA YEVLTELENP AKKEPKIRNC QPQLLLPLTE QTSALAEEIK GLEIESLTPL
     AALNKLYELK KKAEEQGL