ID   MUTS_DEHMB              Reviewed;         858 AA.
AC   A5FQC0;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=DehaBAV1_1029;
OS   Dehalococcoides mccartyi (strain ATCC BAA-2100 / JCM 16839 / KCTC 5957 /
OS   BAV1).
OC   Bacteria; Chloroflexi; Dehalococcoidia; Dehalococcoidales;
OC   Dehalococcoidaceae; Dehalococcoides.
OX   NCBI_TaxID=216389;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-2100 / JCM 16839 / KCTC 5957 / BAV1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Lowry S., Clum A.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.,
RA   Ritalahti K.M., Loeffler F., Richardson P.;
RT   "Complete sequence of Dehalococcoides sp. BAV1.";
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000688; ABQ17609.1; -; Genomic_DNA.
DR   RefSeq; WP_011929265.1; NC_009455.1.
DR   AlphaFoldDB; A5FQC0; -.
DR   SMR; A5FQC0; -.
DR   KEGG; deb:DehaBAV1_1029; -.
DR   PATRIC; fig|216389.18.peg.1084; -.
DR   HOGENOM; CLU_002472_4_0_0; -.
DR   OMA; TPMMAQY; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..858
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000075554"
FT   BINDING         613..620
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   858 AA;  95692 MW;  B9B7C329E92939E4 CRC64;
     MENTTPLRKQ YLDIKKNYPE AIVFFRLGDF YETFEEDARI AARELEIVLT SREMGKGLKV
     PLAGIPYHAL DNYLSRLINK GYKVAICEQV TKPGETKGLV QRQVTRLVTP GTVVEPNLLQ
     TKQNNFLLSL YLTEDSCGLA FADISTSEFG CTQTNIGELE AEISRLSPAE IILPKNQSLN
     LPIHLKATIS KLDGYYFEAD IAREHLLRHF ECQNLSAYGC ENMPLAISAA GALLNYLEET
     QKSSLKQLER LSVYTTADYM QMDSHTLSNL EIFRSSGGNS LKGSLLGILD QTRTAMGGRL
     LRKFLGQPLL KQSDIEKRLS AVDYFFEESL ARTSLAKSLG QIADMERMAN RIRQKTILPR
     ELISLKNSLE TVSAIHRQFG LMPPPRLAYF LNGLKPLPEM LDIINKTITD DPPSTLGDGK
     VIRAGFDPEM DKLCSLAGDA RTFLSQMETR ERERTGIKSL KLGYNRVFGY YIEISNANLG
     DMPPEFIRKQ TLVNAERFIT PELKEYENLI LNAKERLLEM ETGLYEQVLN QLGGFYSALL
     ANAAALAALD VLSAFAEVAV RNSYVRPVFH PENRLDIRKG RHPMVEQGLG YGSFVANDIS
     LSAEDCQIII LTGPNMAGKS TYLKQTALIV LMAQIGSYVP AETAELCLTD RIFTRIGARE
     DLSAGQSTFM VEMVETASIL NTATSRSLLI LDEIGRGTST YDGLAIAQAV VEYIHSQPSL
     TAKTLFATHY HELVELASYL PRVKNYNIAV SEDRGEVVFL HKIVPGGVDK SYGIHVAKLA
     GLPKWVIKRA YEVLTELENP AKKQPKSRTC QPQLQLPMTG QTSVLEEEIK ELEIESLTPL
     AALNKLYELK KKAEEQGL