ID   MUTS_DEHMC              Reviewed;         858 AA.
AC   Q3ZYA0;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=cbdbA1137;
OS   Dehalococcoides mccartyi (strain CBDB1).
OC   Bacteria; Chloroflexi; Dehalococcoidia; Dehalococcoidales;
OC   Dehalococcoidaceae; Dehalococcoides.
OX   NCBI_TaxID=255470;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBDB1;
RX   PubMed=16116419; DOI=10.1038/nbt1131;
RA   Kube M., Beck A., Zinder S.H., Kuhl H., Reinhardt R., Adrian L.;
RT   "Genome sequence of the chlorinated compound-respiring bacterium
RT   Dehalococcoides species strain CBDB1.";
RL   Nat. Biotechnol. 23:1269-1273(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AJ965256; CAI83231.1; -; Genomic_DNA.
DR   RefSeq; WP_011309582.1; NC_007356.1.
DR   AlphaFoldDB; Q3ZYA0; -.
DR   SMR; Q3ZYA0; -.
DR   KEGG; deh:cbdbA1137; -.
DR   HOGENOM; CLU_002472_4_0_0; -.
DR   OMA; TPMMAQY; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..858
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224366"
FT   BINDING         613..620
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   858 AA;  95701 MW;  FED2BADFEB77B992 CRC64;
     MENTTPLRKQ YLDIKKNYPE AIVFFRLGDF YETFEEDARI AARELEIVLT SREMGKGLKV
     PLAGIPYHAL DNYLSRLINK GYKVAICEQV TKPGETKGLV QRQVTRLVTP GTVVEPNLLQ
     TKQNNFLLSL YLTEDSCGLA FADISTSEFG CTQTNISELE AEISRLSPAE IILPKNQSLN
     LPIHLKATIS KLDGYYFEAD IARERLLRHF ECQNLSAYGC ENMPLAISAA GALLNYLEET
     QKSSLKQLER LSVYTTADYM QMDSHTLSNL EIFRSSGGNS LKGSLLGILD QTKTAMGGRL
     LRKFLGQPLL KQSDIEKRLS AVDYFFEESL ARTSLAKSLG QIADMERMAN RIRQKTILPR
     ELISLKNSLE TVSAIHRQFG LMPPPRLAYF LNGLKPLPEM LDIINKTITD DPPSTLGDGK
     VIRAGFDPEM DKLCSLAGDA RTFLSQMETR ERERTGIKSL KLGYNRVFGY YIEISNANLG
     DVPPEFIRKQ TLVNAERFIT PELKEYENLI LNAKERLLEM ETGLYEQVLN QLGGFYSALL
     ANATALAALD VLSAFAEVAV RNSYVRPVFH PENRLDIRKG RHPMVEQGLG YGSFVANDIS
     LSAEDCQIII LTGPNMAGKS TYLKQTALIV LMAQIGSYVP AETAELCLTD RIFTRIGARE
     DLSAGQSTFM VEMVETASIL NTATSRSLLI LDEIGRGTST YDGLAIAQAV VEYIHSQPSL
     TAKTLFATHY HELVELASYL PRVKNYNIAV SEDRGEVVFL HKIVPGGVDK SYGIHVAKLA
     GLPKWVIKRA YEVLTELENP AKKQPKSRTC QSQLQLPMTG QTSVLEEEIK ELEIESLTPL
     AALNKLYELK KKAEEQGL