ID   MUTS_DESAH              Reviewed;         895 AA.
AC   C0QFS1;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=HRM2_23940;
OS   Desulforapulum autotrophicum (strain ATCC 43914 / DSM 3382 / VKM B-1955 /
OS   HRM2) (Desulfobacterium autotrophicum).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfobacterales;
OC   Desulfobacteraceae; Desulforapulum.
OX   NCBI_TaxID=177437;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43914 / DSM 3382 / VKM B-1955 / HRM2;
RX   PubMed=19187283; DOI=10.1111/j.1462-2920.2008.01825.x;
RA   Strittmatter A.W., Liesegang H., Rabus R., Decker I., Amann J., Andres S.,
RA   Henne A., Fricke W.F., Martinez-Arias R., Bartels D., Goesmann A.,
RA   Krause L., Puehler A., Klenk H.P., Richter M., Schuler M., Gloeckner F.O.,
RA   Meyerdierks A., Gottschalk G., Amann R.;
RT   "Genome sequence of Desulfobacterium autotrophicum HRM2, a marine sulfate
RT   reducer oxidizing organic carbon completely to carbon dioxide.";
RL   Environ. Microbiol. 11:1038-1055(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001087; ACN15489.1; -; Genomic_DNA.
DR   RefSeq; WP_015904254.1; NC_012108.1.
DR   AlphaFoldDB; C0QFS1; -.
DR   SMR; C0QFS1; -.
DR   STRING; 177437.HRM2_23940; -.
DR   EnsemblBacteria; ACN15489; ACN15489; HRM2_23940.
DR   KEGG; dat:HRM2_23940; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_0_7; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000442; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..895
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000202733"
FT   REGION          824..849
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         632..639
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   895 AA;  100060 MW;  E8E61D26D479161C CRC64;
     MTVKKETPMM EQYLSIKKRY PDTILFYRMG DFYEMFLDDA LKAAPVLEIA LTSRNKTQED
     PIPMCGVPHR AADVYIAKLI ESGLKVAVCE QMEDPRSAQG IVKREVVRVI TPGMILNEDL
     LDKKSNNFLA ALCICQGAAG LACMDISTGM FRTTQTVAVN GKVPLSLVDE ALRIDAKELL
     LPASFKGDPT YSQLIKAFET IQISYVGNEN FKLDSARERL KEKFRTRSLE GFGCEDLTAG
     TAAAGAILSY VQETQLRETD HVLTLERYEL NTYLIIDDRS CRNLELLKNI QTSDKKGSLI
     SVLDCTITAM GGRLLKAWIR YPLISMDGIE ARLDAVAEAK ENPGIRNSLR THLKDVYDLE
     RLGSKISMGH ANPRDLTALK ISLYKLPLLF KDLNQLSASL LQGHGIEDRE KVSTELFELA
     DLINQTIRED APLALNEGGI ICDGYSPELD EILEIARNGR SWIAKTGAKE KEKTGLSSLK
     IKFNKVFGYF IEVSKIQSQQ VPDHYIRKQT LVNAERFITD ELKEVESKVL NAQERRSSLE
     YALFCKVRES IVQRTPSIFK IAQFLAEVDV VLALATTAEE NNYTRPALNK DQVLDIEDGR
     HPVVEKMVVG ERYIPNSIRL DNTSDQVQII TGPNMAGKST VLRQVALISL MAQMGSFVPA
     ARADLCIIDR IFTRVGALDN LSLGQSTFMV EMEETANIVN NAKENSLVIL DEIGRGTSTF
     DGMSIAWAVA EYLHDLDGKG VKTLFATHYH ELTRLEKLKP RVKNFNIAVK EFNDNIIFLR
     RLVPGGTNKS YGIQVARLAG VPDAVITKAK QILASIEQSP DQVVTQDKKQ VKKQTKNNHS
     ARSGSRQQQM DLFAGHDYDE IIKVLDQTDI STMTPIDALN LIHELKQKIR SKAMI