ID   MUTS_DESAL              Reviewed;         889 AA.
AC   B8FJL5;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Dalk_3998;
OS   Desulfatibacillum aliphaticivorans.
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfobacterales;
OC   Desulfobacteraceae; Desulfatibacillum.
OX   NCBI_TaxID=218208;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AK-01;
RX   PubMed=21651686; DOI=10.1111/j.1462-2920.2011.02516.x;
RA   Callaghan A.V., Morris B.E., Pereira I.A., McInerney M.J., Austin R.N.,
RA   Groves J.T., Kukor J.J., Suflita J.M., Young L.Y., Zylstra G.J., Wawrik B.;
RT   "The genome sequence of Desulfatibacillum alkenivorans AK-01: a blueprint
RT   for anaerobic alkane oxidation.";
RL   Environ. Microbiol. 14:101-113(2012).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001322; ACL05684.1; -; Genomic_DNA.
DR   RefSeq; WP_015948732.1; NC_011768.1.
DR   AlphaFoldDB; B8FJL5; -.
DR   SMR; B8FJL5; -.
DR   PRIDE; B8FJL5; -.
DR   EnsemblBacteria; ACL05684; ACL05684; Dalk_3998.
DR   KEGG; dal:Dalk_3998; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_7; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000739; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..889
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000117282"
FT   REGION          869..889
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        869..883
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         622..629
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   889 AA;  98942 MW;  557B7DFC60406215 CRC64;
     MSAPKVTPMV RQYLSIKAEH PDSILFFRMG DFYEMFFEDA EKASKALDIT LTSRNKNDPD
     PVPMCGVPHH SANGYVARLV EQGFKVAICD QVQDPSEAKG LVERKVVQVV TPGMQLDGRY
     LDASQNNFVC AAVTGRGGVG LAFLDISTGA FLVTQVTTPE SAFQEILRMG PKELVLPEKF
     EENARAAAAM RMADQLPTSR LEGKDFENAR TRDRLLEHFK TRSLEGFGIQ DLPLAVRAAG
     ALLHYVQQAQ RQEITHVTKI QAYFQDQFLW IDDNSARNLE LLKNIRNGTR QGALISVLDK
     TVTAMGARLM SYLLRYPLID PQVINLRLDA VEQAKDLARV RDEVREALKE VHDLERLRSR
     TALGHANGRD LAAMGESLKQ LPRLWALLKE NFESPLLCGE ATDDGLTDVA DLIDRSIRED
     APPGVRDGGM IKPGFNEELD EVAALATDVK GLIAGLEAQE KERTGISTLK VRYNKVFGYY
     IEISKNQTKS IPPHYVRKQT LVNAERYITD ELKEFETKVL GAEERRVALE YNIFTQIVDR
     INGENDRLEK ASHLIAWVDV LAALGHVADH NGYCRPVVDM GQTLDLQESR HPVVEKMLPG
     QRFVPNNIAM NNLDQQILMI TGPNMAGKST VLRQAALCVI MAQMGSFVPA EKAVVGVVDK
     IFTRVGALDN LSQGESTFMV EMQETANILN NVSHRSLVIL DEIGRGTSTF DGLSIAWAVA
     EYLHDYKDHG VKTMFATHYH ELTDLTKTHP RVKNFNIAVN EWNDEIIFLH SLVEGGTNKS
     YGIQVARLAG IPASVIRRSK QVLQTIEDSE EARVAYSAKA SGKSGKKDVQ VQMSLFPTPG
     ELAAQALERM DINVMTPLEA MNVLSELQQR VKRPEKAPAD VTAETEDQE