ID   MUTS_DESDA              Reviewed;         927 AA.
AC   B8J008;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Ddes_1181;
OS   Desulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949 / MB).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC   Desulfovibrionaceae; Desulfovibrio.
OX   NCBI_TaxID=525146;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27774 / DSM 6949 / MB;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA   Goodwin L., Pitluck S., Sims D., Lu M., Kiss H., Meineke L., Brettin T.,
RA   Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Ovchinnikova G., Hazen T.C.;
RT   "Complete sequence of Desulfovibrio desulfuricans subsp. desulfuricans str.
RT   ATCC 27774.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001358; ACL49085.1; -; Genomic_DNA.
DR   RefSeq; WP_012624810.1; NC_011883.1.
DR   AlphaFoldDB; B8J008; -.
DR   SMR; B8J008; -.
DR   STRING; 525146.Ddes_1181; -.
DR   EnsemblBacteria; ACL49085; ACL49085; Ddes_1181.
DR   KEGG; dds:Ddes_1181; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_7; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..927
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000118680"
FT   REGION          904..927
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        913..927
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         646..653
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   927 AA;  103825 MW;  C5B9B38A6612CD86 CRC64;
     MSEPTFKMTP MFEHYMSIKA DYPDALLFYR MGDFYELFFD DAELAARELQ ITLTSRSRDP
     NNPIPMCGVP WHAVDTYVAQ LVDKGYHIAI CDQVEDPKTS KGLVKRAVTS VKTPGTVLDD
     ANLSTKSHNY LGALCPGSDA EKGGFAWLDV STGQWSGVDF RRQTELWQWV LKMAPRELLV
     PEGFQPPART LLEGIRLVRL PLSRFDLKRS TERVLAAQGV REAAALGLEG REEIMRACGA
     LLAYLAQTQM RSPEHLQPFL RLDLSRRLII DEVTERNLEI FTRLNGRKGK GTLRHVLDET
     MTPMGGRLLE DMLRHPWREI SPIVRIQDAV EWFYVDDGRR TALREALNGV YDMERLSTRI
     SLNQGSPRDF IALRNSLAAL PQVFTALIEP TTSLLLRPDQ EKDASENTSQ ENGLTQPRAL
     TELLKTWDAM EDCAQLLQSA LVDNPPPVIT DGGLFKSGYN AELDRLLDLA EHGEQKLQAM
     LAEEQSTTGI AKLKLGYNRV FGYYFEVSRA AHSGTVPYHF IRRQSLANAE RFTTEALKNL
     EEELLSASDK RKALEYTLFQ DLRQHMADQR ERIAHMAQLI AHLDYWQSLA QVGRLNNWCR
     PGLETDGNLT IREGRHPVVE AMIGRANFVP NDFRLDEKRR LCLLTGPNMA GKSTVLRQVA
     IICLLAQMGS MVPATSARLG LVDRLFSRVG ASDNLAQGQS TFMVEMMETA RILRQATKRS
     LIILDEIGRG TSTYDGVALA WAMVEDLSRR AQGELRTLFA THYHELTALE GRVDGVFTMN
     IAISEYSGDI LFLHKLVPGP ADRSYGVEVA RLAGVPGPVV QRARAILANL ERGRDVARKA
     VVSAVCLPGI DLPETGPEED MPVLQAAPPR SEHPVIELLR QIEPEELSPL DALKTLMEWK
     KLWSAQPGSA EQGESPDKHD EGKNSRG