ID   MUTS_DESHY              Reviewed;         862 AA.
AC   Q24X61;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=DSY1592;
OS   Desulfitobacterium hafniense (strain Y51).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Desulfitobacteriaceae;
OC   Desulfitobacterium.
OX   NCBI_TaxID=138119;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Y51;
RX   PubMed=16513756; DOI=10.1128/jb.188.6.2262-2274.2006;
RA   Nonaka H., Keresztes G., Shinoda Y., Ikenaga Y., Abe M., Naito K.,
RA   Inatomi K., Furukawa K., Inui M., Yukawa H.;
RT   "Complete genome sequence of the dehalorespiring bacterium
RT   Desulfitobacterium hafniense Y51 and comparison with Dehalococcoides
RT   ethenogenes 195.";
RL   J. Bacteriol. 188:2262-2274(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AP008230; BAE83381.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q24X61; -.
DR   SMR; Q24X61; -.
DR   STRING; 138119.DSY1592; -.
DR   EnsemblBacteria; BAE83381; BAE83381; DSY1592.
DR   KEGG; dsy:DSY1592; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001946; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..862
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335147"
FT   BINDING         613..620
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   862 AA;  96552 MW;  23F8BDD484BD5E53 CRC64;
     MPRQSISKES PTMTTPMMQQ YKSIKSQAPD AILFFRLGDF YEMFGEDART AAPILEIALT
     GRDSGGGERI PMCGVPHHAV DGYLLKLVSA GYKVALCEQV EDPQAAKGIV KREIIRIISP
     GTLTDSLVEQ ANNFLAAVYH EQDWGLAFVD VSTGEFTVFQ TESLDILTTE LSRIRPSELL
     LPAELLKAKH WRPYYLTQRE KKTYQHTLLE ERFTEQRELF QEFPTAMKAA NGLWQYILET
     SPGIDPSHIL KVNAYRPEHW MLLDPWTRRN LELTESIRGQ GKKGTLLSVL DFTKTAFGGR
     LLRRWIEQPL LLKGEIEKRL DYVEALVEDS FLRGDLIQLF GKVYDLERLM GKVSYGTANA
     RDLLSLAQTL GVLPQLRALL AEGKSEPLQA FIPALEGLDP LAATLEQAIN PEAPISLKDG
     NLLKAGYSVE IDELRSISSG GKAWVAKLES MEKDRTGIRS LKVGYNKVFG YYIEVTHANS
     HLIPAEYIRK QTLANAERFI TPELKEYEQK ILGAEEKVTQ LEYQLFLELR ETVRGQAAKI
     LEAAHALAEI DVYTSLAEAA VRHHYSRPVM KGEGGLTIIE GRHPVVESML QDTSFVPNDT
     ILTEDKHLAL ITGPNMAGKS TYMRQVALIV LMAQIGSFVP AQQATIPIAD HIFTRVGASD
     DLASGQSTFM VEMYEVAHIL RHVTPQSLII LDEVGRGTAT YDGLSIAWAV AEYLAGQENK
     PKTLFATHYH ELTDLEETHS GIFNLHVGVR EHGEEIVFLH KIIPGRADRS YGIQVAKLAG
     LPANLLHRAK IILHELESSA KESRQEHLFN KEKATQLSLF EVQPLDPLLQ EVSELSVEDL
     TPRQALDYLF DLKERIKAAD SL