ID   MUTS_DESOH              Reviewed;         881 AA.
AC   A8ZXH5;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Dole_1126;
OS   Desulfococcus oleovorans (strain DSM 6200 / JCM 39069 / Hxd3).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfobacterales;
OC   Desulfosudaceae; Desulfosudis.
OX   NCBI_TaxID=96561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 6200 / JCM 39069 / Hxd3;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Wawrik B.,
RA   Richardson P.;
RT   "Complete sequence of Desulfococcus oleovorans Hxd3.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000859; ABW66933.1; -; Genomic_DNA.
DR   RefSeq; WP_012174551.1; NC_009943.1.
DR   AlphaFoldDB; A8ZXH5; -.
DR   SMR; A8ZXH5; -.
DR   STRING; 96561.Dole_1126; -.
DR   EnsemblBacteria; ABW66933; ABW66933; Dole_1126.
DR   KEGG; dol:Dole_1126; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_7; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000008561; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..881
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000093621"
FT   BINDING         626..633
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   881 AA;  96610 MW;  CE8B28867D402AB8 CRC64;
     MASTGATPMM QQYLSIKEQH RDAILFYRMG DFYEMFFEDA QTAAPVLEIA LTSRNKNDTD
     PIPMCGVPVK AADGYIGRLI ENGFKVAVCE QTEDPAAAKG LVRRDVVRIV TPGMIIDNAL
     LEKGTNNYVV CLAHADGVVG FASVDISTGT FRVCESSDLR AVRHELLRIA PREVVIPESG
     ADDAALSPFV SLFPPAIRTT LANREFDYRT ACQRLTDQFQ TRSLEGFGCR GLKPGIVAAG
     ALLSYVNDTQ RQKASHLTGL EVYSIDQYLL MDEVTCRNLE LVANLRNNGR QGTLIDVLDA
     CVTAMGSRLL RRWMLYPLLS AEAINRRLDA VAEAKEGLGT RKAVRELLKQ VYDIERLTSR
     AVMGRVTPRD LLALKQTLFA LPGLATELKS FDSPFFSFAG EPGPEGLDKL AGLADLLKAA
     VREDAPVSIA DGGVINPDYH PRLAELVTIS RDGKSSLARL EATEKEKTGI STLKVRYNKV
     FGYYIEVPRS QVGAVPAHYV RKQTLVNGER YITDELKVFE EKALGAEEQR VRLEQELFAD
     IVGRVTACSP MLFAVARVAA GIDVLCALAQ VADDHDYVRP EMLSGGEIII EEGRHPVVER
     MLSGERYVPN SITLNDTDRQ LLIITGPNMA GKSTVLRKVA LFSVMAQMGS FVPARRAAMG
     VVDRLFTRVG ALDNLASGQS TFMVEMEETA NIINNATPKS LVVIDEIGRG TSTYDGLSIA
     WAVAEALHDL HGRGVKTLFA THYHELTELE NTRPRVKNFH IAVKEWNDTI IFLRKLVEGS
     TNRSYGIQVA RLAGIPGPVI ARAKKILLDI EQGTYSFEAK SGTAPGTGQS GPVQLSLFTP
     PEQMLVDRLQ KVDISTMTPL EALNCLHELQ QKAHAISETD G