ID   MUTS_DESPS              Reviewed;         879 AA.
AC   Q6AQ04;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=DP0840;
OS   Desulfotalea psychrophila (strain LSv54 / DSM 12343).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfobacterales;
OC   Desulfocapsaceae; Desulfotalea.
OX   NCBI_TaxID=177439;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 12343 / LSv54;
RX   PubMed=15305914; DOI=10.1111/j.1462-2920.2004.00665.x;
RA   Rabus R., Ruepp A., Frickey T., Rattei T., Fartmann B., Stark M., Bauer M.,
RA   Zibat A., Lombardot T., Becker I., Amann J., Gellner K., Teeling H.,
RA   Leuschner W.D., Gloeckner F.-O., Lupas A.N., Amann R., Klenk H.-P.;
RT   "The genome of Desulfotalea psychrophila, a sulfate-reducing bacterium from
RT   permanently cold Arctic sediments.";
RL   Environ. Microbiol. 6:887-902(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CR522870; CAG35569.1; -; Genomic_DNA.
DR   RefSeq; WP_011188085.1; NC_006138.1.
DR   AlphaFoldDB; Q6AQ04; -.
DR   SMR; Q6AQ04; -.
DR   STRING; 177439.DP0840; -.
DR   EnsemblBacteria; CAG35569; CAG35569; DP0840.
DR   KEGG; dps:DP0840; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_7; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000602; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..879
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224367"
FT   REGION          824..845
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         629..636
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   879 AA;  99041 MW;  7949ECF2141362FF CRC64;
     MPKLKITPMM QQYFKLKEQH PHTILFYRMG DFYEMFFEDA ITASKILGIT LTSRNKKSDS
     AQIPMCGIPY HALQGYLAKM VEAGKRVAIC EQVEDPSTAQ GIVKREVVQI VTPGVVTDNQ
     LLDAKSNNFV TAISRGKNNR YGLSFLDITT GEFIVADFAG SDGEADILDQ LTRLTPTELL
     VSEEELEDFA ETIDLATTLI PGLCITPRPH HLFDFDQSHE KLLEHFAVIS LDGFGCETLV
     EGQIAAAILL DYIEETQKSA IHHIEKLSRL ELDAILQIDD SSRRNLELTQ TIVGGNRSGS
     LLSVLDLTTT PMGARFLKQA ILFPLQDRAR ILRRLNAVGY FFNNSEARHQ IRELLDQVYD
     IERLNSRITL GSANGRDMLA MKQSLARLPE MLTELRKCDT DELIEIEQTL DTLEDLHQLL
     DKSIHPDPPT NIREGNLIRE GYNAELDEII VLLRDGKKLI LDLEAKERER TGIAKLKVSY
     NRVFGYFIEV SRAQSSRVPE HYIRKQTLVN AERFITPELK EFETKVLGAE DRRLELEYQL
     FATVRNELAS HSSRFLATAH QLALLDFYAS AAEVSQQYNY HRPEIRDDGS LEIREGRHPV
     IERSLPAGKF VPNDVYLDQA ENEILVITGP NMAGKSTVLR QTALIVLMAQ MGYYVPADSA
     RIGVVDRIFT RVGAMDDLRR GQSTFMVEMS ETANILNNAT PRSLVILDEI GRGTSTYDGL
     SIAWAVTEHL VQKDGIGVKT MFATHYHELT DLARRYARIQ NYSIAVREWQ KSVIFLHKLI
     KGGTSRSYGI QVAALAGVPA QVVERAHEIL HSIESGDFLA GEKVGGQPQK ELSEHKPHQP
     SLFAPPTDEI RTKIREMDLD ELTPRQALDA LYALKEMTV