ID   MUTS_DESVV              Reviewed;         905 AA.
AC   A1VDD9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Dvul_1437;
OS   Desulfovibrio vulgaris subsp. vulgaris (strain DP4).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC   Desulfovibrionaceae; Desulfovibrio.
OX   NCBI_TaxID=391774;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DP4;
RX   PubMed=19737303; DOI=10.1111/j.1462-2920.2009.01946.x;
RA   Walker C.B., Stolyar S., Chivian D., Pinel N., Gabster J.A., Dehal P.S.,
RA   He Z., Yang Z.K., Yen H.C., Zhou J., Wall J.D., Hazen T.C., Arkin A.P.,
RA   Stahl D.A.;
RT   "Contribution of mobile genetic elements to Desulfovibrio vulgaris genome
RT   plasticity.";
RL   Environ. Microbiol. 11:2244-2252(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000527; ABM28455.1; -; Genomic_DNA.
DR   RefSeq; WP_011792254.1; NC_008751.1.
DR   AlphaFoldDB; A1VDD9; -.
DR   SMR; A1VDD9; -.
DR   PRIDE; A1VDD9; -.
DR   EnsemblBacteria; ABM28455; ABM28455; Dvul_1437.
DR   KEGG; dvl:Dvul_1437; -.
DR   HOGENOM; CLU_002472_3_1_7; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000009173; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..905
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008056"
FT   REGION          388..410
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          826..847
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        830..846
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         638..645
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   905 AA;  101548 MW;  D9FA35D705880DC7 CRC64;
     MTNPSPKLTP MFEQYLRIKE DYPDALLFYR MGDFYELFFD DAETTARELQ IALTCRNPNA
     ELKAPMCGVP YHAVEGYISQ LLDKGYRVAI CEQIEDPKEA KGLVKRAVTR VLTPGTVIDD
     ANLDAKEHNY LGALFWNQDA EAGAFAWVDV STGEWSGLYS RKLAELWQWA QKMAPRELLL
     PEGVDTPAMA TLGTTQTVRV PARSHFDLKS GTERVMRAQG VADLGSLGLE GKPELVRACA
     ALLAYLAQTQ KQELSHLAPF KPLNLGRHLI IDEVTERNLE LFHRLDGRKG PGTLWHILDR
     TLTPMGGRLL EERMHHPWRE AGPIRETQQV VEWLFQDDVR REALRTALDL VYDLERLSTR
     IFLNRATPKD FIALRQSLSA LPAVRATLER PANPEGTYPT DAETSGDTLP KPLSDMLSAW
     DDLADYADLL RRALTDNPPH LVTEGGLFRP GFDPDLDELL DLAEHGEARL QELLAEEQTV
     SGLPKLKLGY NRVFGYFFEL SRAGADSVPE HFVRRQTLAN AERFTTERLK ELEEKLVSAT
     DRRKTLEYRL FQSLRDTVAE ARPRVLFMAD MLAHLDFWQS LADVARRNGW VRPDVHTGHD
     IVIREGRHPV VEAMQGSASF VPNDLRMDEK RRLLLITGPN MAGKSTVLRQ TAIICLLAQM
     GAFVPAREAS IGIADRIFSR VGASDNLAQG QSTFMVEMME TARILRQASK RSLVILDEIG
     RGTSTFDGMA LAWAVVEELT RRAGGGIRTL FATHYHEITS LEGRIPGVHN MNIAIREWNG
     DIVFLRRLVP GPADKSYGIE VARLAGVPHS VVQRARELLA DLERTRDAAR GTNSAPSRQT
     LPGLDLPSKQ EQVDTIVAPP PCSGVEHPLL VALRDIDTDD MTPLEALKRI TEWKQLWGTT
     REDRS