ID   MUTS_DICNV              Reviewed;         861 AA.
AC   A5EX62;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=DNO_1303;
OS   Dichelobacter nodosus (strain VCS1703A).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Cardiobacteriales;
OC   Cardiobacteriaceae; Dichelobacter.
OX   NCBI_TaxID=246195;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VCS1703A;
RX   PubMed=17468768; DOI=10.1038/nbt1302;
RA   Myers G.S.A., Parker D., Al-Hasani K., Kennan R.M., Seemann T., Ren Q.,
RA   Badger J.H., Selengut J.D., Deboy R.T., Tettelin H., Boyce J.D.,
RA   McCarl V.P., Han X., Nelson W.C., Madupu R., Mohamoud Y., Holley T.,
RA   Fedorova N., Khouri H., Bottomley S.P., Whittington R.J., Adler B.,
RA   Songer J.G., Rood J.I., Paulsen I.T.;
RT   "Genome sequence and identification of candidate vaccine antigens from the
RT   animal pathogen Dichelobacter nodosus.";
RL   Nat. Biotechnol. 25:569-575(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000513; ABQ13473.1; -; Genomic_DNA.
DR   RefSeq; WP_012031593.1; NC_009446.1.
DR   AlphaFoldDB; A5EX62; -.
DR   SMR; A5EX62; -.
DR   STRING; 246195.DNO_1303; -.
DR   EnsemblBacteria; ABQ13473; ABQ13473; DNO_1303.
DR   KEGG; dno:DNO_1303; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000248; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..861
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335149"
FT   BINDING         613..620
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   861 AA;  96680 MW;  6FEE71BC9C0BF0B7 CRC64;
     MNTKISEHTP AMQQYLTIKE DFPDLLLFYR MGDFYELFFD DAKKAGALLN ITVTARGKIR
     GKPIPMAGVP AHALENYLAK LVKQGMSAVI CEQVGEVGKG LVERAVTRII TPGTLTDENL
     LDEARDSILL SLFCFQNNYF FAYADITRGD FQLTMGLNEQ ELQSEIERLR PAEILMPETA
     NVPAFITALK PHRQPDWYFD SDSSYRLICE YYQTTTIDGF GIAPDDPALS AAGCLLQYLH
     DTHKYHLPPL KPLQKQHDHQ YLLLDATTRR NLELEYTLNG ESKHSLIATI NRCSTAAGVR
     TLKRWINQPL IQHEYILERQ EAVTALLTHA DLDEIAKTLR ATADIERITT RIALQTAKPR
     ELAQLRDTLM QLPAINALLQ TSAAHSPLLA AATQALMHCP QLGDLLMKAL VEAPPLTLKE
     GGIFAAGYLP ELDALHELTD HSAQLLEKME QEEKAQTGLN TLKIGFNRVH GYYIDIPRSQ
     AANAPAHWIR RQTLKNSERY VTESLKTLEE RLLNAQDEAL ALEKQAYTEL LITLDKQRDD
     LYRLATALAE SDVLTCFARL AKEHHYCRPQ FSNQIEIQIT AGRHPVVEQL SAQPFIANDL
     VLHQKRQLLI LTGPNMGGKS TYMRQTALIV ILALAGSYVP AKEARIGRIN RIFTRIGASD
     DLAGGRSTFM VEMTETANIL NNADEHSLVI MDEIGRGTST FDGLSLAWAV ADHLLQKNRA
     LTLFATHYFE LTALVERHQH GANIHLSAAE DQEHIVFLYH IEEGATSKSY GLHVAKLAGV
     PQAVIHNANA KLRQLEEKRV PQRAHQALLP IESQKPSLSP QIKNILQQIQ EINPDELSPK
     AAHEWLYQLK TLVRDLDKNE L