ID   MUTS_DINSH              Reviewed;         877 AA.
AC   A8LPD4;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Dshi_3466;
OS   Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Dinoroseobacter.
OX   NCBI_TaxID=398580;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16493 / NCIMB 14021 / DFL 12;
RX   PubMed=19741735; DOI=10.1038/ismej.2009.94;
RA   Wagner-Dobler I., Ballhausen B., Berger M., Brinkhoff T., Buchholz I.,
RA   Bunk B., Cypionka H., Daniel R., Drepper T., Gerdts G., Hahnke S., Han C.,
RA   Jahn D., Kalhoefer D., Kiss H., Klenk H.P., Kyrpides N., Liebl W.,
RA   Liesegang H., Meincke L., Pati A., Petersen J., Piekarski T.,
RA   Pommerenke C., Pradella S., Pukall R., Rabus R., Stackebrandt E., Thole S.,
RA   Thompson L., Tielen P., Tomasch J., von Jan M., Wanphrut N., Wichels A.,
RA   Zech H., Simon M.;
RT   "The complete genome sequence of the algal symbiont Dinoroseobacter shibae:
RT   a hitchhiker's guide to life in the sea.";
RL   ISME J. 4:61-77(2010).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000830; ABV95199.1; -; Genomic_DNA.
DR   AlphaFoldDB; A8LPD4; -.
DR   SMR; A8LPD4; -.
DR   STRING; 398580.Dshi_3466; -.
DR   EnsemblBacteria; ABV95199; ABV95199; Dshi_3466.
DR   KEGG; dsh:Dshi_3466; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_5; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000006833; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..877
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000075555"
FT   BINDING         627..634
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   877 AA;  94649 MW;  468D6C8B43379072 CRC64;
     MSSKTVTPMM AQYLEIKQDH ADALLFYRMG DFYEMFFDDA VEAAAALDIA LTKRGKHDDA
     DIPMCGVPVH AAEGYLLTLI RKGFRVAVCE QMEDPAEAKK RGSKSVVRRE VVRLVTPGTL
     TEASLLEARR HNYLAAFAKV RDDSALAWVD ISTGEFRVMA CPAARLSVDL ARLAPREVLL
     AEGNDLRSLV EEHEAAATEL GRASFDSTAA VDRLCRLYGV ADLEAFGSFE RADLSAMGAI
     VGYLELTQKG KLPLLRKPVK ERAQHGLQID AATRRNLELT QSLSGGREGA LLTVIDRTVT
     AQGARLLARR LASPSADLSI IRTRHEGVRY ALEAPEILDT VRTALRQVPD MDRALSRLAL
     DRGGPRDLAA IRNGLAQAAT LAEALPDDAL PPLWAQSKSR FFGHDALRDL LEKALIAEPP
     LLTRDGGFVA SGYNVDLDEA RQLRDEGRGV IAGMQAEYAE ATGIASLKVK HNNVLGYFIE
     TTATHADKML SPPLSDRFIH RQTTANAVRF TTVELSEMET RILNAGGRAL ALEKSIFEEL
     RQAVIVAAAE LSDCARALAE LDVVTALAVL ARDEDWCAPK VDDSRAFEIS GGRHPVVEAA
     LRASGTPFIR NDCDLSEGAA PIWLLTGPNM AGKSTFLRQN ALIAILAQMG SYVPATAARI
     GLVAQVFSRV GASDDLARGR STFMVEMVET AAILNQAGDR ALVILDEIGR GTATYDGLSI
     AWATLEHLHG VNRCRALFAT HYHEMTGLAA QLSGVENATV AVKEHDGDVI FLHEVRRGAA
     DRSYGVQVAK LAGLPPSVVA RAREVLKTLE SGERSGGNPA KALLEDLPLF ANAAPPPPPA
     APTSALEARL ADISPDALSP REALDLVYEL KSLADRD