ID   MUTS_ECO24              Reviewed;         855 AA.
AC   A7ZQH3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=EcE24377A_3030;
OS   Escherichia coli O139:H28 (strain E24377A / ETEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=331111;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E24377A / ETEC;
RX   PubMed=18676672; DOI=10.1128/jb.00619-08;
RA   Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F.,
RA   Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R.,
RA   Henderson I.R., Sperandio V., Ravel J.;
RT   "The pangenome structure of Escherichia coli: comparative genomic analysis
RT   of E. coli commensal and pathogenic isolates.";
RL   J. Bacteriol. 190:6881-6893(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABV18168.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000800; ABV18168.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_001696757.1; NC_009801.1.
DR   AlphaFoldDB; A7ZQH3; -.
DR   SMR; A7ZQH3; -.
DR   EnsemblBacteria; ABV18168; ABV18168; EcE24377A_3030.
DR   KEGG; ecw:EcE24377A_3030; -.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   Proteomes; UP000001122; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..855
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335151"
FT   BINDING         616..623
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   855 AA;  95605 MW;  15AD54029828C4F7 CRC64;
     MNENIDKDFS SHTPMMQQYL KLKAQHPEIL LFYRMGDFYE LFYDDAKRAS QLLDISLTKR
     GASAGEPIPM AGIPYHAVEN YLAKLVNQGE SVAICEQIGD PATSKGPVER KVVRIVTPGT
     ISDEALLQER QDNLLAAIWQ DSKGFGYATL DISSGRFRLS EPADRETMAA ELQRTNPAEL
     LYAEDFAEMS LIEGRRGLRR RPLWEFEIDT ARQQLNLQFG TRDLVGFGVE NAPRGLCAAG
     CLLQYAKDTQ RTTLPHIRSI TMEREQDSII MDAATRRNLE ITQNLAGGAE NTLASVLDCT
     VTPMGSRMLK RWLHMPVRDT RVLLERQQTI GALQDFTAEL QPVLRQVGDL ERILARLALR
     TARPRDLARM RHAFQQLPEL RAQLETVDSA PVQALREKMG EFAELRDLLE RAIIDTPPVL
     VRDGGVIASG YNEELDEWRA LADGATDYLE RLEVRERERT GLDTLKVGFN AVHGYYIQIS
     RGQSHLAPIN YMRRQTLKNA ERYIIPELKE YEDKVLTSKG KALALEKQLY EELFDLLLPH
     LEALQQSASA LAELDVLVNL AERAYTLNYT CPTFIDKPGI RITEGRHPVV EQVLNEPFIA
     NPLNLSPQRR MLIITGPNMG GKSTYMRQTA LIALMAYIGS YVPAQKVEIG PIDRIFTRVG
     AADDLASGRS TFMVEMTETA NILHNATEYS LVLMDEIGRG TSTYDGLSLA WACAENLANK
     IKALTLFATH YFELTQLPEK MEGVANVHLD ALEHGDTIAF MHSVQDGAAS KSYGLAVAAL
     AGVPKEVIKR ARQKLRELES ISPNAAATQV DGTQMSLLSV PEEISPAVEA LENLDPDSLT
     PRQALEWIYR LKSLV