ID   MUTS_EDWI9              Reviewed;         852 AA.
AC   C5BGI4;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=NT01EI_3249;
OS   Edwardsiella ictaluri (strain 93-146).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Edwardsiella.
OX   NCBI_TaxID=634503;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146;
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT   "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001600; ACR70390.1; -; Genomic_DNA.
DR   RefSeq; WP_015872472.1; NC_012779.2.
DR   AlphaFoldDB; C5BGI4; -.
DR   SMR; C5BGI4; -.
DR   STRING; 67780.B6E78_07875; -.
DR   PRIDE; C5BGI4; -.
DR   EnsemblBacteria; ACR70390; ACR70390; NT01EI_3249.
DR   GeneID; 7961082; -.
DR   KEGG; eic:NT01EI_3249; -.
DR   PATRIC; fig|634503.3.peg.2895; -.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001485; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..852
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000202735"
FT   BINDING         614..621
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   852 AA;  94578 MW;  C5AE81556EF2D0DD CRC64;
     MTTTDNLDAH TPMMQQYLRL KAQHPDILLF YRMGDFYELF YDDARRASQL LDISLTKRGA
     SAGEPIPMAG VPYHAVENYL AKLVQLGESV AICEQIGDPA ASKGPVERKV VRIVTPGTVS
     DEALLSERQD NLLAAIWQSP NGFGYATLDI SSGRFRAAEP QDADSMAAEL QRTNPAELLY
     PEEFTSMALI EQRRGLRRRP MWEFELETAR QQLNLQFGTR DLSGFGVEQA PQALRAAGCL
     LQYAKDTQRT MLPHIRAITM ERQQDGIIMD AATRRNLELT QNLAGGQENT LAAVLDASVT
     AMGSRMLKRW LHMPIRDRQA LQRRQDAIEA LLPLIDDLQP LLRQVGDLER ILARLALRSA
     RPRDLARMRV AFQQLPTLQT LLGERGSEAL APLARQAGRF DALCELLERA LVETPPVLVR
     DGGVIASGYH AELDEWRALA DGASDYLDRL EVREREKLGL DTLKVGFNAV HGYYIQVSRG
     QSHLVPIHYV RRQTLKNAER YIIPELKEYE DKVLTSKGKA LALEKQLYDE LFDLLLPHLA
     ALQQSATALA ELDVLSGLAE RADRYGYVRP QLSERTGINI DEGRHPVVEQ VLREPFIANP
     LTLSGARRML VITGPNMGGK STYMRQAALI VLMAHIGSFV PAQRAVIGPV DRIFTRVGAA
     DDLASGRSTF MVEMTETANI LHNATEHSLV LMDEIGRGTS TYDGLSLAWA CAESLASRIK
     AMTLFATHYF ELTTLPEKLE GVYNVHLDAL EHGETIAFMH SVQDGAASKS YGLAVAALAG
     VPREVIKRAR QKLRELETLS QHGNQSQADG AQLPLLVEAE PSAALEALTA IDPDVLTPRQ
     ALDWLYRLKG ML