ID   MUTS_EHRCJ              Reviewed;         804 AA.
AC   Q3YSJ8;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Ecaj_0260;
OS   Ehrlichia canis (strain Jake).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Anaplasmataceae; Ehrlichia.
OX   NCBI_TaxID=269484;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Jake;
RX   PubMed=16707693; DOI=10.1128/jb.01837-05;
RA   Mavromatis K., Doyle C.K., Lykidis A., Ivanova N., Francino M.P., Chain P.,
RA   Shin M., Malfatti S., Larimer F., Copeland A., Detter J.C., Land M.,
RA   Richardson P.M., Yu X.J., Walker D.H., McBride J.W., Kyrpides N.C.;
RT   "The genome of the obligately intracellular bacterium Ehrlichia canis
RT   reveals themes of complex membrane structure and immune evasion
RT   strategies.";
RL   J. Bacteriol. 188:4015-4023(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000107; AAZ68307.1; -; Genomic_DNA.
DR   RefSeq; WP_011304385.1; NC_007354.1.
DR   AlphaFoldDB; Q3YSJ8; -.
DR   SMR; Q3YSJ8; -.
DR   STRING; 269484.Ecaj_0260; -.
DR   EnsemblBacteria; AAZ68307; AAZ68307; Ecaj_0260.
DR   KEGG; ecn:Ecaj_0260; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000435; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..804
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224369"
FT   BINDING         614..621
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   804 AA;  91004 MW;  896D36BBEA882935 CRC64;
     MNHDRKITPI MQQYMMLKNQ YKECLLFYRL GDFYELFFDD AIETSKVLNI VLTKKGNVPM
     CGVPFHSSES YLNRLVKLGY KVAICEQLET PEEAKKRGYK ALVKRDVVRI VTPGTILEDS
     LLEAKENNYL CCIVNVNDNY AIAWLELSTG LFHYNTTDLR KIDSDLLRIN PKEVLISDKL
     VELDLIYSTL KKYKFSITQY SSSFFDTSRS YNTLCSVYGI STLKGLGDLK DEEIAVCGSL
     LEYVKATQKG NLPKLEFPKA YGDRDFMFID AAALRNLELF NTQSGDLEGS LISSIDYTIT
     ACGGRLLKRC LSAPLACSYA INRRLDIVEF FVNNKVLYKN VRETLRGIAD IERILTRVKV
     GRCSPKDLYA LKLTLDKTCI LVNLLSKFDT SVVSDFCTRL GRYDDLCKTL SNVLIPNNVS
     NVKDGGFIKP DYDVQLSEYI YIQNYSNNLI QELRDKYRNI TNIQNLKILY NNILGYYVEV
     SANHLINDKD FIHRQTLANS IRYTTSELKA LESKIISARD AAISLEVKIF GQLCTRIIEH
     ADEITMTAHA VSEIDMLTSF AELAIQYSYT RPVVDDSYEF NIQKGRHPVV ERNGKFVAND
     IDLAQMQRVH LITGPNMAGK STFLRQNALI GILAHIGSFV PAYSAHIGVI DKIFSRVGAS
     DNIAFGYSTF MVEMTETAAI INQATDKSFV ILDEIGRGTG TYDGLSIAWS VIEQIHNVNK
     SRAIFATHYH ELSKLDECLE NIKCFCMKVE EWNGKVVFLH EIIPGSTNKS YGIHVAKLAG
     FPQSVLDRAE DLMNKLKANE DLLT