ID   MUTS_EHRCR              Reviewed;         804 AA.
AC   Q2GG13;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=ECH_0824;
OS   Ehrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Anaplasmataceae; Ehrlichia.
OX   NCBI_TaxID=205920;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC CRL-10679 / Arkansas;
RX   PubMed=16482227; DOI=10.1371/journal.pgen.0020021;
RA   Dunning Hotopp J.C., Lin M., Madupu R., Crabtree J., Angiuoli S.V.,
RA   Eisen J.A., Seshadri R., Ren Q., Wu M., Utterback T.R., Smith S., Lewis M.,
RA   Khouri H., Zhang C., Niu H., Lin Q., Ohashi N., Zhi N., Nelson W.C.,
RA   Brinkac L.M., Dodson R.J., Rosovitz M.J., Sundaram J.P., Daugherty S.C.,
RA   Davidsen T., Durkin A.S., Gwinn M.L., Haft D.H., Selengut J.D.,
RA   Sullivan S.A., Zafar N., Zhou L., Benahmed F., Forberger H., Halpin R.,
RA   Mulligan S., Robinson J., White O., Rikihisa Y., Tettelin H.;
RT   "Comparative genomics of emerging human ehrlichiosis agents.";
RL   PLoS Genet. 2:208-222(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000236; ABD45507.1; -; Genomic_DNA.
DR   RefSeq; WP_011452830.1; NC_007799.1.
DR   AlphaFoldDB; Q2GG13; -.
DR   SMR; Q2GG13; -.
DR   STRING; 205920.ECH_0824; -.
DR   EnsemblBacteria; ABD45507; ABD45507; ECH_0824.
DR   KEGG; ech:ECH_0824; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000008320; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..804
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008060"
FT   BINDING         614..621
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   804 AA;  90792 MW;  4AC126558F04F43D CRC64;
     MNHDSKITPI MQQYMMLKSQ YKEYLLFYRL GDFYELFFDD AIETSRILNI VLTKKGNVPM
     CGVPFHSSES YLNRLVKLGY KIAICEQLET SEEAKKRGYK ALVKRDVVRI VTPGTILEDS
     LLEAKENNYL SCIVNVDHNY AIAWLELSTG LFYYHTTELH KLDSDLFRIN PKEVLISDKL
     VELDSIYSIL RKYKFSVTQY SGSFFDVSRS YNTLCNVYGI STLKGLGDLK NEEIAVCGSL
     LEYVKATQKG NLPQLEFPKA YSKGDFMFID AAALRNLELF CTQSGDLEGS LISSIDYTIT
     ACGGRLLKRC LSAPLACSHA INRRLDIVEF FVNDRTLCRG VRETLRGIAD IERILTRIKV
     GKCSPKDLYA LKLTLDKIFV LLDLLHKFDS SVVGDFCSRL GKYDDLCKTL DDVLIPNNVN
     NVKDGGFINP DYDAQLSEYI YIQSYSNDLI QELRDKYRNI TNIQSLKILY NNILGYYVEV
     SSSYLISDKD FIHRQTLANS IRYTTSELKA LESKIISARD AAINLEVKIF GQLCTCIIEV
     ADKITMTAHA IAEIDMLTSF AELAIQYSYT KPIVDDSYEF NIKKGRHPVV ERNGKFVAND
     IDLSLMQRVH LITGPNMAGK STFLRQNALI GILAHIGSFV PAQHAHIGVI DKVFSRVGAS
     DNIASGHSTF MVEMTETAAI INQATDKSFV ILDEIGRGTG TYDGLSIAWS VIEQIHNVNK
     SRAIFATHYH ELSKLDRYLE NIKCFCMKVE EWNGKVVFLH EIIPGSTNKS YGIHVAKLAG
     FPQSVLDRAE DLMSKLKANE DLLT