ID   MUTS_EHRRW              Reviewed;         804 AA.
AC   Q5HBQ7; Q5FE56;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=Erum2700, ERWE_CDS_02740;
OS   Ehrlichia ruminantium (strain Welgevonden).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Anaplasmataceae; Ehrlichia.
OX   NCBI_TaxID=254945;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Welgevonden;
RX   PubMed=15637156; DOI=10.1073/pnas.0406633102;
RA   Collins N.E., Liebenberg J., de Villiers E.P., Brayton K.A., Louw E.,
RA   Pretorius A., Faber F.E., van Heerden H., Josemans A., van Kleef M.,
RA   Steyn H.C., van Strijp M.F., Zweygarth E., Jongejan F., Maillard J.C.,
RA   Berthier D., Botha M., Joubert F., Corton C.H., Thomson N.R., Allsopp M.T.,
RA   Allsopp B.A.;
RT   "The genome of the heartwater agent Ehrlichia ruminantium contains multiple
RT   tandem repeats of actively variable copy number.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:838-843(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Welgevonden;
RX   PubMed=16547041; DOI=10.1128/jb.188.7.2533-2542.2006;
RA   Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y.,
RA   Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D.;
RT   "Comparative genomic analysis of three strains of Ehrlichia ruminantium
RT   reveals an active process of genome size plasticity.";
RL   J. Bacteriol. 188:2533-2542(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CR767821; CAH57987.1; -; Genomic_DNA.
DR   EMBL; CR925678; CAI26768.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5HBQ7; -.
DR   SMR; Q5HBQ7; -.
DR   STRING; 254945.Erum2700; -.
DR   EnsemblBacteria; CAI26768; CAI26768; ERWE_CDS_02740.
DR   KEGG; eru:Erum2700; -.
DR   KEGG; erw:ERWE_CDS_02740; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_5; -.
DR   OMA; TPMMAQY; -.
DR   BioCyc; ERUM254945:ERUM_RS01480-MON; -.
DR   Proteomes; UP000001021; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..804
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224371"
FT   BINDING         614..621
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   804 AA;  90587 MW;  451446E3D7AC251C CRC64;
     MTNSNSITPV MQQYVTLKQQ YKEYLLFYRL GDFYELFFDD AIKTSKILNI VLTKKGNVPM
     CGVPFHSSET YLNKLVKLGY KIAICEQLET SEEARKRGYK SLVKRDVVRI VTPGTIVEDS
     LLEAKESNYL ACIVMIKDSC AIAWLELSTG LFCYHMTYIS KLDSDLLRIG PKELLVADDL
     LEIEAVYSII KKYRFSITQY SSSFFDENRA YNTLCNVYGV STLKGLGDLK GVEISVCGSL
     LEYVIATQKG SLPKLGFPKA YVQSDFMFID AAALRNLELF STQSGELEGS LIASIDFTVT
     ASGGRLLKRC LSAPLASADA INRRLSVVEF FVNNQNLYKS VRQVLRGIAD IERILTRVKI
     ARCSPKDLYS LKLTLEKTCE LVELLCKFNI DIISEFCLRL GRYEDLICIL NNSLLQNSVS
     SVKDGGFINP ECDAQLSEYI YIQECSNQLI QELRDRYRNI TNIQSLKILY NNILGYYVEV
     SSNHLIDDKN FIHRQSLANN VRYTTTELKE LESKIISAKD ASISLEIKIF GQLCSDVIKY
     ADKITITAHT IAEIDMLTSF AELAVQYSYS KPIIDDSYEF NIKKGKHPVV ERNGKFIAND
     INLSSEQRVH LITGPNMAGK STFLRQNALI GILAHIGSFV PAEYAHIGVI DKVFSRVGAS
     DNIVCGYSTF MVEMIETAAV INQATERSFV ILDEIGRGTG TYDGLSIAWS VIEQIHNVNK
     SRAIFATHYH ELSKLDKYLK HIKCFCMKVE EWDGKVVFLH EIIPGASDKS YGIHVAKLAG
     FPQSVVNRAE YLMDKLKTNE DLLT