ID   MUTS_ELUMP              Reviewed;         851 AA.
AC   B2KB17;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Emin_0214;
OS   Elusimicrobium minutum (strain Pei191).
OC   Bacteria; Elusimicrobia; Elusimicrobia; Elusimicrobiales;
OC   Elusimicrobiaceae; Elusimicrobium.
OX   NCBI_TaxID=445932;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pei191;
RX   PubMed=19270133; DOI=10.1128/aem.02698-08;
RA   Herlemann D.P.R., Geissinger O., Ikeda-Ohtsubo W., Kunin V., Sun H.,
RA   Lapidus A., Hugenholtz P., Brune A.;
RT   "Genomic analysis of 'Elusimicrobium minutum,' the first cultivated
RT   representative of the phylum 'Elusimicrobia' (formerly termite group 1).";
RL   Appl. Environ. Microbiol. 75:2841-2849(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001055; ACC97776.1; -; Genomic_DNA.
DR   RefSeq; WP_012414391.1; NC_010644.1.
DR   AlphaFoldDB; B2KB17; -.
DR   SMR; B2KB17; -.
DR   STRING; 445932.Emin_0214; -.
DR   EnsemblBacteria; ACC97776; ACC97776; Emin_0214.
DR   KEGG; emi:Emin_0214; -.
DR   HOGENOM; CLU_002472_3_1_0; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001029; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..851
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000117288"
FT   BINDING         608..615
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   851 AA;  93638 MW;  0D10A79BEB664E8F CRC64;
     MQESKQLTPL MRQYNDIKSK NTDLIVFFRL GDFYEMFDSD AREASRILGI ALTQRGGVPM
     CGVPYHAAAN YISKIIKEGR KVGICEQVGT GEGKSKLFER KIVRVITPGT VIEDNMLQSN
     VSNYLVCVFT DKKGWGAAAI DVSTGEFWVT EQADDISLNG LSCMLAALNP AEILLDKITL
     DRVKSSMMIP GSVATTIVPR EESSQIPSNW PSQSVWAGKK TALTCALTAI KYINVNEPGF
     KDLLIPFYKE ISDYLALDEN AVRTLELVSQ NGARKGSLWH LLDFTVTPMG GRTLKNWILN
     PLLNLADIEK RQNCVSNFYD NPLAYEELKV ILADISDIER IMSRVGTGNA GPRDLAGLAR
     SLAVHGALKN WFDKYGAVVP YLKENILSKI TVIEDLANLL NSAIEPNPPI KISDGGIIKQ
     GFNAELDDLR NTKNNSSKTL AELCEREKAK TGISTLKVGF NSVFGYYIEV SKGQSGKVPF
     SYTRKQTLTN AERFITEELK EIEDKILHAE EKILRLETSL FDSVRKHLAE HIGVMRSFAK
     AIAELDVYSN LAHCAKVYKF TKPVIDESNI LKAADLRHPV VEACLPLGSF VPNDIDLGGE
     TQISVITGPN MGGKSVYLKQ AAVLVILAQM GSFVPAASAH VGIVDKIMTR IGAQDAIAMG
     QSTFMVEMKE TSHILASCTP KSLILLDEVG RGTSTFDGIS IAWAITEFLY KPHGGGAKVL
     FATHYFELTD LENKYKGIKN FHAEVQEYKD ADGQSKIAFL YKIKEGAGDK SYGIHVGELA
     GLPATVIVRA KKVIKDLEAK KGTSVSKKED DIVGDLFSSP IVEEIKLVNT DAVTPMQALQ
     MILEWKKRIN S