ID   MUTS_ENT38              Reviewed;         853 AA.
AC   A4WDU5;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Ent638_3211;
OS   Enterobacter sp. (strain 638).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Enterobacter.
OX   NCBI_TaxID=399742;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=638;
RX   PubMed=20485560; DOI=10.1371/journal.pgen.1000943;
RA   Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D.,
RA   Vangronsveld J., Newman L., Monchy S.;
RT   "Genome sequence of the plant growth promoting endophytic bacterium
RT   Enterobacter sp. 638.";
RL   PLoS Genet. 6:E1000943-E1000943(2010).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000653; ABP61875.1; -; Genomic_DNA.
DR   RefSeq; WP_015960204.1; NC_009436.1.
DR   AlphaFoldDB; A4WDU5; -.
DR   SMR; A4WDU5; -.
DR   STRING; 399742.Ent638_3211; -.
DR   EnsemblBacteria; ABP61875; ABP61875; Ent638_3211.
DR   KEGG; ent:Ent638_3211; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000230; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..853
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000071275"
FT   BINDING         614..621
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   853 AA;  95161 MW;  AC6B6E4A84BC55CA CRC64;
     MSTIENLTAH TPMMQQYLKL KAQHPEILLF YRMGDFYELF YDDAKRASQL LDISLTKRGA
     SAGEPIPMAG IPHHAVENYL AKLVNQGESV AICEQIGDPA TSKGPVERKV VRIVTPGTIS
     DEALLQERQD NLLAAIWQDS KGYGYAALDI SSGRFRLSEP ADRETMAAEL QRTNPAELLY
     AEDFAEMALI DGRRGLRRRP LWEFEIDTAR QQLNLQFGTR DLIGFGVENA PRGLCAAGCL
     LQYVKDTQRT TLPHIRSITM ERQQDSIIMD AATRRNLEIT QNLAGGVENT LAAVLDSTVT
     PMGSRMLKRW LHMPVRDTNV LVSRQQTIGA LQDRFTELQP VLRQVGDLER ILARLALRTA
     RPRDLARMRH AFQQLPTLRA QLAEVNSTPV QKLRETMGEF TELCELLERA VVEAPPVLVR
     DGGVIAPGYH EELDEWRALA DGATDYLDKL EIRERERLGL DTLKVGYNAI HGYYIQISRG
     QSHHAPIHYV RRQTLKNAER YIIPELKEYE DKVLTSKGKA LALEKQLYEE LFDMLMPHLA
     DLQASASALA ELDVLINLAE RADTLNYACP TFIDKPGIRI TEGRHPVVEQ VLREPFIANP
     LNLSPQRRML IITGPNMGGK STYMRQTALI ALLAYIGSYV PAQKVEIGPI DRIFTRVGAA
     DDLASGRSTF MVEMTETANI LHNATENSLV LMDEIGRGTS TYDGLSLAWA CAESLANKIK
     ALTLFATHYF ELTQLPEKME GVANVHLDAL EHGDTIAFMH TVQDGAASKS YGLAVAALAG
     VPKEVIKRAR QKLRELESLS PNAAATQVDG SQMSLLMPAE ETSPAMEALE NLDPDSLTPR
     QALEWIYRLK NLV