ID   MUTS_ENTFA              Reviewed;         858 AA.
AC   Q82ZA2;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; Synonyms=hexA;
GN   OrderedLocusNames=EF_3167;
OS   Enterococcus faecalis (strain ATCC 700802 / V583).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=226185;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700802 / V583;
RX   PubMed=12663927; DOI=10.1126/science.1080613;
RA   Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R.,
RA   Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H.,
RA   Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C.,
RA   DeBoy R.T., Durkin S.A., Kolonay J.F., Madupu R., Nelson W.C.,
RA   Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M.,
RA   Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M.;
RT   "Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus
RT   faecalis.";
RL   Science 299:2071-2074(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AE016830; AAO82841.1; -; Genomic_DNA.
DR   RefSeq; NP_816771.1; NC_004668.1.
DR   RefSeq; WP_002378992.1; NZ_KE136524.1.
DR   AlphaFoldDB; Q82ZA2; -.
DR   SMR; Q82ZA2; -.
DR   STRING; 226185.EF_3167; -.
DR   EnsemblBacteria; AAO82841; AAO82841; EF_3167.
DR   KEGG; efa:EF3167; -.
DR   PATRIC; fig|226185.45.peg.411; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001415; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..858
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115097"
FT   BINDING         609..616
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   858 AA;  96877 MW;  B3FC28C44D60AA24 CRC64;
     MPQKTKNTPM MEQYLSIKAQ YKDAFLFYRL GDFYELFYED AINAAQILEL TLTSRNRNAD
     DPIPMCGVPY HAAQGYIDTL IEQGYKVAIC EQVEDPKTTK GMVKREVVQL VTPGTVMNSK
     GLEAKDNNYL TAVLTDGNQF GFAYVDLSTG ELKTAVLADE EGVLNEASAL QTKEMVLGSG
     IPESLKENLS LRLNIIFSTQ ETVEENAEFS FLTNELINPL EIEITGKLLS YLSVTQKRSL
     SHIQKAVEYQ PDHFLKMDHY SKFNLELSQS IRTGQKKGTL LWLLDETKTA MGGRLLKQWL
     DRPLIQERQI KARQEMVQSL LNAYFERLDL QAALTNVYDL ERLAGRVAFG SVNGRDLIQL
     RTSLEQVPTI RQLIVGINQG EWDDLLVDLN PVEDLVALIA TAINEEAPLQ ITEGKVIKDG
     YNDQLDEYRD AMRNGKQWLA ELEAKERQET GIKNLKIGYN RVFGYFIEIT KSNLANLEEG
     KYERKQTLAN AERFITPELK ELERLILEAE EKSVELEYQL FLAVREQVKT NIDRLQTLAK
     TISAVDVLQS FATISERYQY VRPTLRSNTK NLAIVEGRHP VVEKVLGHQE YIPNSIRMNP
     ETDILLITGP NMSGKSTYMR QLALTVVMAQ IGCFVPAESA EMPIFDQIFT RIGASDDLIA
     GQSTFMVEMM EANQALRHAT PNSLILFDEL GRGTATYDGM ALAQAIIEYI HREVQAKTLF
     STHYHELTVL DETLKGLKNI HVGAVEKDGE VVFLHKMMEG PADKSYGIHV AKIAGLPSPL
     LERAATILSA LEAEETTIPI SVHHEEVSEV HEETEQLSLF KEVSTEELSV IDTLKKMNLL
     EMTPLDALNM LHQLQKRI