ID   MUTS_ERWT9              Reviewed;         853 AA.
AC   B2VG22;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=ETA_26940;
OS   Erwinia tasmaniensis (strain DSM 17950 / CFBP 7177 / CIP 109463 / NCPPB
OS   4357 / Et1/99).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Erwinia.
OX   NCBI_TaxID=465817;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17950 / CFBP 7177 / CIP 109463 / NCPPB 4357 / Et1/99;
RX   PubMed=18462403; DOI=10.1111/j.1462-2920.2008.01639.x;
RA   Kube M., Migdoll A.M., Mueller I., Kuhl H., Beck A., Reinhardt R.,
RA   Geider K.;
RT   "The genome of Erwinia tasmaniensis strain Et1/99, a non-pathogenic
RT   bacterium in the genus Erwinia.";
RL   Environ. Microbiol. 10:2211-2222(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CU468135; CAO97740.1; -; Genomic_DNA.
DR   RefSeq; WP_012442398.1; NC_010694.1.
DR   AlphaFoldDB; B2VG22; -.
DR   SMR; B2VG22; -.
DR   STRING; 465817.ETA_26940; -.
DR   PRIDE; B2VG22; -.
DR   EnsemblBacteria; CAO97740; CAO97740; ETA_26940.
DR   KEGG; eta:ETA_26940; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001726; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..853
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000093625"
FT   BINDING         616..623
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   853 AA;  94934 MW;  A5E28031ECAE121B CRC64;
     MSLNDNTNLS SHTPMMQQYL RLKAEHPEIL LFYRMGDFYE LFYDDAKRAS QLLEISLTKR
     GSSAGEPIPM AGVPYHAVEN YLAKLVHLGE SVAICEQIGD PALSKGPVER KVVRIVTPGT
     ISDEALLNER QDNLLAAIWQ STRGFGYATL DISSGRFRLA EPTDRETMAA ELQRTNPAEL
     LYPEDFAAMD LIENRRGLRR RALWEYELDT ARQQLNLQFA TRDLSGFGVE QAHHALRAAG
     CLLQYVKDTQ RTSLPHIRSL TIERQQDGII MDAATRRNLE ITQNLAGGSD NTLASVLDKT
     VTPMGSRMLK RWLHMPLRNA QTIALRQQSI RTLQDLNDSL PPLLRQVGDL ERILARLALR
     TARPRDLARM RHAFQQLPQL NNELADSDNA HLQTLRSQMG EFTELRELLE HAIVETPPVL
     VRDGGVIAPG YNQELDEWRA LADGATDYLD RLEIREREKL GLDTLKVGFN GVHGYYIQVS
     RGQSHLVPIH YVRRQTLKNA ERYIIPELKE YEDKVLTSKG KALSLEKALY EQLFDRLLPH
     LAALQDSAAA LAELDVLTNL AERAWTLNYS CPTLSDKPGI KLTGGRHPVV EQVLKDPFIA
     NPLSLSPQRR MLVVTGPNMG GKSTYMRQAA LITLMAHIGS FVPAEQAIIG PIDRIFTRVG
     AADDLASGRS TFMVEMTETA NILHNATEYS LVLMDEIGRG TSTYDGLSLA WACAESLANR
     IKAMTLFATH YFELTTLPEQ IEGVANVHLD AVEHGDTIAF MHSVQEGAAS KSYGLAVAAL
     AGVPKDVIKR ARQKLKELEA LSGSAASTRA DGSQLPLLVE ETSPAVEALE ALDPDSLSPR
     QALEWIYRLK SLV