ID   MUTS_ERYLH              Reviewed;         879 AA.
AC   Q2N5V9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=ELI_14200;
OS   Erythrobacter litoralis (strain HTCC2594).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Erythrobacteraceae; Erythrobacter/Porphyrobacter group; Erythrobacter.
OX   NCBI_TaxID=314225;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HTCC2594;
RX   PubMed=19168610; DOI=10.1128/jb.00026-09;
RA   Oh H.M., Giovannoni S.J., Ferriera S., Johnson J., Cho J.C.;
RT   "Complete genome sequence of Erythrobacter litoralis HTCC2594.";
RL   J. Bacteriol. 191:2419-2420(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000157; ABC64932.1; -; Genomic_DNA.
DR   RefSeq; WP_011415754.1; NC_007722.1.
DR   AlphaFoldDB; Q2N5V9; -.
DR   SMR; Q2N5V9; -.
DR   STRING; 314225.ELI_14200; -.
DR   PRIDE; Q2N5V9; -.
DR   EnsemblBacteria; ABC64932; ABC64932; ELI_14200.
DR   KEGG; eli:ELI_14200; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_5; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000008808; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..879
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335150"
FT   BINDING         629..636
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   879 AA;  93839 MW;  4AA16E9F66B9BA2C CRC64;
     MAGKSTPMME QYLALKAEAS AGGDDCLLFY RMGDFFELFF EDAKVASGIL DIALTARGKD
     SGEPVPMCGV PVHSAEGYLA RLIKAGQRVA IAEQVETPEE AKARARREGK PVSKVLVKRD
     IVRFVTAGTL TEEALLEPRR ANVLAAVCEV RGTLGIAHCD ISTGRMELEE CAPDAMDAAL
     ARLGASEVVA PENWDGAPAD ATLRPPSEFA SDEGEARLKA IHDVATLDGF GDFSRAMLAA
     AGGLIGYLDH AGRGTLPFLL PPVVARGEAK LAMDAATRSS LEILVSQQDA RSGSLIAAVD
     RCVTGAGARQ LAEDLAAPLT EREPIERRLA LVHFFHADPL LRADLREVMR AVPDLARALG
     RIVAGRGSPR DLGQIRDGLA EARRIRDYLA SKPDRPALLD DLLPAMGGHG ALVDHLQRAL
     VPAPPTAREQ GGYIAAGFDA ALDELRDVSG NARRAIAALE TRYRGETGIE RLKIKHNGVL
     GYFIEVPAKH ADALMAPDSG FTHRQTMAGA VRFNSLQLHE EASRISEAGG RALAAEEAHF
     EELVATVGDA REAIARTADA LARIDVAAGL AERAAEGDWC KPAITDERVL DIVGGRHPVV
     EAALKQAGDR FVPNDCTLSG SDRLWLIGGP NMGGKSTFLR QNALIVLLAQ AGSYVPASTA
     TIGLVDRLFS RVGASDNLAR GRSTFMVEMV ETAAILAQAS DRSFVILDEV GRGTSTYDGL
     ALAWAVVEAV HETIQCRCLF ATHYHELARL AETCDSLSLH HVRAREWKGD LVLLHELAEG
     PADRSYGLAV AKLAGVPAPV VKRARSVLEK LEKGREETGG LAAGLGELPL FAAALEERPE
     KIGDSMREKL AALDIDALSP REALDLLYAL KTEASQTED