ID   MUTS_EXIS2              Reviewed;         843 AA.
AC   B1YMD7;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Exig_1044;
OS   Exiguobacterium sibiricum (strain DSM 17290 / CIP 109462 / JCM 13490 /
OS   255-15).
OC   Bacteria; Firmicutes; Bacilli; Bacillales;
OC   Bacillales Family XII. Incertae Sedis; Exiguobacterium.
OX   NCBI_TaxID=262543;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17290 / CIP 109462 / JCM 13490 / 255-15;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kiss H., Chertkov O., Monk C.,
RA   Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F.,
RA   Land M., Hauser L., Kyrpides N., Mikhailova N., Vishnivetskaya T.,
RA   Rodrigues D.F., Gilichinsky D., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome of Exiguobacterium sibiricum 255-15.";
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001022; ACB60524.1; -; Genomic_DNA.
DR   RefSeq; WP_012369947.1; NC_010556.1.
DR   AlphaFoldDB; B1YMD7; -.
DR   SMR; B1YMD7; -.
DR   STRING; 262543.Exig_1044; -.
DR   EnsemblBacteria; ACB60524; ACB60524; Exig_1044.
DR   KEGG; esi:Exig_1044; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001681; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..843
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000093626"
FT   BINDING         598..605
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   843 AA;  94156 MW;  4E42B68659ECAF6B CRC64;
     MEAVHNTPMM KQYFSIKADY PDAFLFYRLG DFYELFFEDA KQVAHELELT LTAKNGKNAE
     HPIPMCGVPH HAANGYIEQL IERGYKVALC DQVEDPKLTK GLVKREVVQV ITPGTLMSSL
     TEKENRYLVA VVEQDGRFGI ARGDVSTGES ALTSVATLDA VAKELSIILP REIVVTSSEH
     EAALSHLQIP LTQSTRRETH PHGDRAIDAA QADAFAVLYA YMHDTQKRSL AHLQPAIVYE
     AADFMQLEPN TVKNLELVRS ARTGDKKGSL LGLLDVTGTA MGGRMLKRWL EKPLLSQHTI
     AERLDAVEEL LAHYFERQQL KDTLREVYDL ERLVAKVGYG TASARDLVQL KSTLRLIPRI
     QAALEELFSD RLGQLALGLD PHDELTDLLD RAFVEAPPIS TKDGGMIRTG FDPALDELLV
     ASKDGKTWLA TLEASERQAT GIKTLKIGYN RVFGYYIEVS RANAKLLPEG RYERKQTLAN
     AERYVTPELK EKEALILGAE EKSITLEYEL FCQVRDQVKT HIESLQRVSR RIAELDVLVA
     LAETAERHDY VRPVTLTGRN VMIENGRHPV IETVLPRGEY VANGINLNED REMLLITGPN
     MSGKSTYMRQ FALIALLHQI GSFVPASRAE LPIFDQIFTR IGAADDLVSG QSTFMVEMVE
     TQEALTRATD RSLILLDEIG RGTSTYDGMA LAQAIVEHIA EHVGAKTLFS THYHELTVLE
     DSMPRLANVH VRAVEQDGRV VFLHEVRDGK ADQSYGIHVA RLADLPDALI ARAEVLLSEF
     EQTEERTVVS PKEPVVQAEP VDQLSLFAET DPVRETVQTL DLINMTPLEA LNTLYRLQAE
     ARK