ID   MUTS_EXISA              Reviewed;         842 AA.
AC   C4L191;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=EAT1b_0103;
OS   Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b).
OC   Bacteria; Firmicutes; Bacilli; Bacillales;
OC   Bacillales Family XII. Incertae Sedis; Exiguobacterium;
OC   unclassified Exiguobacterium.
OX   NCBI_TaxID=360911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1283 / AT1b;
RX   PubMed=21460088; DOI=10.1128/jb.00303-11;
RA   Vishnivetskaya T.A., Lucas S., Copeland A., Lapidus A., Glavina del Rio T.,
RA   Dalin E., Tice H., Bruce D.C., Goodwin L.A., Pitluck S., Saunders E.,
RA   Brettin T., Detter C., Han C., Larimer F., Land M.L., Hauser L.J.,
RA   Kyrpides N.C., Ovchinnikova G., Kathariou S., Ramaley R.F., Rodrigues D.F.,
RA   Hendrix C., Richardson P., Tiedje J.M.;
RT   "Complete genome sequence of the Thermophilic Bacterium Exiguobacterium sp.
RT   AT1b.";
RL   J. Bacteriol. 193:2880-2881(2011).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001615; ACQ69037.1; -; Genomic_DNA.
DR   RefSeq; WP_012726156.1; NC_012673.1.
DR   AlphaFoldDB; C4L191; -.
DR   SMR; C4L191; -.
DR   STRING; 360911.EAT1b_0103; -.
DR   EnsemblBacteria; ACQ69037; ACQ69037; EAT1b_0103.
DR   KEGG; eat:EAT1b_0103; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000716; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..842
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000202736"
FT   BINDING         596..603
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   842 AA;  94686 MW;  1E64D30543E58796 CRC64;
     MQEVHQTPMM KQYFSIKADY PDAFLFYRLG DFYELFFEDA QIVAKELELT LTSKNGKQAE
     HPIPMCGVPH HSAAIYIEQL IEKGFNVAIC EQTEDPKATK GLVKREVIQV ITPGTYMASL
     SEKENRYLVA ISDVAGRFGI ARGDVTTGES WLTTLSSEEA VLREIEGLLP NEVIVEDERL
     ADLLRQTGIP LSIQVDKRES TLAQGAKDEA QRSAFELLFA YLTKTQKRSL DHLQPAVAYE
     VEQHMQLDAN TARNLELFRS ARSGERKGSL LSLLDETTTA MGGRLLKRWL EQPLYTEQGI
     RERQDAVENL VDDFMLRDQL QEELKRVYDI ERLVAKVGYG TANARDLVQL RDTLERMPSV
     RSLLQTVKAD RLQQIEQNLD SFETLSEQLR AALVDSPPIS TKEGGMIRHG YSDELDELLE
     AKANGKSWIA NLEQQERIAT GIKSLKVGYN RVFGYYLEVT KANAKLLEEG RYERKQTLTN
     AERYITPELK EKEALILGAE EKSCTLEYDL FVALREEVKT YTKPLQQLAR SLSELDVLLA
     LAVVAEKREY VRPVTTSHVQ IERGRHPVIE TVLPRGEYVA NDLTLDDTRQ MLLITGPNMS
     GKSTYMRQFA LIAILHQIGS FVPAEAAELP LFDRIFTRIG AADDLVSGQS TFMVEMTETR
     QAVTEATSNS LILLDEIGRG TSTYDGMALA QAIVEYIASS IGAKTLFSTH YHELTVLEDS
     IPSLENVHVR AIERDGRVVF LHEVHPGRAD KSYGIHVAEL AELPDSLIDR ARTILSELES
     EATKPALNEQ SAPPQVEEVS QLSLFESNDA VREQLLKLDL LAMNPIEAMQ ALYELQQTAK
     KG