ID   MUTS_FERNB              Reviewed;         823 AA.
AC   A7HMG4;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Fnod_1250;
OS   Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1).
OC   Bacteria; Thermotogae; Thermotogales; Fervidobacteriaceae;
OC   Fervidobacterium.
OX   NCBI_TaxID=381764;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35602 / DSM 5306 / Rt17-B1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C.,
RA   Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P.;
RT   "Complete sequence of Fervidobacterium nodosum Rt17-B1.";
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000771; ABS61097.1; -; Genomic_DNA.
DR   RefSeq; WP_011994407.1; NC_009718.1.
DR   AlphaFoldDB; A7HMG4; -.
DR   SMR; A7HMG4; -.
DR   STRING; 381764.Fnod_1250; -.
DR   EnsemblBacteria; ABS61097; ABS61097; Fnod_1250.
DR   KEGG; fno:Fnod_1250; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_0; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000002415; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..823
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335152"
FT   BINDING         605..612
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   823 AA;  94259 MW;  C5686EB6B502DE45 CRC64;
     MEKSLFDTKN LKITPMMKQY LDIKDKYKDS ILLFRLGDFY EAFFDDALTV SKILNIVLTK
     RQDAPMAGIP YHALDNYLKK LVDAGYKVAI CEQMEDPALA KGIVKREVTR VITPGTIIED
     ELLTTENNYM MSLYETKDGK ISCILTDSST GEVIIKQMES IDEISDFLQT HRVSQIICPE
     NFYDKIVNIA RVLGIFVDKL DDWYYENDIQ TIKEAYGLVS IEHFELGEAS KPLCATIKYI
     NYTLNRQAKL KVPKTLDESK YMTLDSTTVE NLSLIPGDKG KNLYDVLNKT NTPMGGRLLK
     WVILHPLKDR NEIEKRLWYV EAFYEDPLLT NEIREYLNGV YDLERIINRL EYDSAKPKDL
     ISLKTTLEVV EPIKEALSTN EKLIQLAQML PDLSQIKVKI ENTLLEEFEG ELGEGKIIKE
     GVSKELDEYR ELLYHSNEKL KEFEERERAK TGIQKLKVSF NNVFGYYIEI PKGQVKFAPQ
     EYTRIQTLVN AERYTTTELK EFEQKILAAK EKVEILEKTI FKQICDELKG YTQDLRKLAE
     MLSWIDVYSN FAYVSKLYSY SKPEISDSEF KVLNGRHPVV ERFVDEFVPN DIYMSDELRM
     YILTGPNMSG KSTYIRQVGL IALMTQIGCF VPAQYAKVPV FDRIFTRMGA RDDISTGKST
     FLTEMNEVAL ILSKATQKSL VLLDEVGRGT STFDGISIAW AMSEYIYNEI KCKTIFATHF
     TELTELSEGY SGIKNLTVDV KETPDGVVFL HKVVEGVADR SYGIEVAAIA GLPESIIERA
     KEILNIIVEK SDLEKKVGVL KEGQMKKIKA TKKSVPEGQM KLF