ID   MUTS_FINM2              Reviewed;         856 AA.
AC   B0S1C1;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=FMG_0743;
OS   Finegoldia magna (strain ATCC 29328 / DSM 20472 / WAL 2508)
OS   (Peptostreptococcus magnus).
OC   Bacteria; Firmicutes; Tissierellia; Tissierellales; Peptoniphilaceae;
OC   Finegoldia.
OX   NCBI_TaxID=334413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29328 / DSM 20472 / WAL 2508;
RX   PubMed=18263572; DOI=10.1093/dnares/dsm030;
RA   Goto T., Yamashita A., Hirakawa H., Matsutani M., Todo K., Ohshima K.,
RA   Toh H., Miyamoto K., Kuhara S., Hattori M., Shimizu T., Akimoto S.;
RT   "Complete genome sequence of Finegoldia magna, an anaerobic opportunistic
RT   pathogen.";
RL   DNA Res. 15:39-47(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AP008971; BAG08161.1; -; Genomic_DNA.
DR   RefSeq; WP_012290601.1; NC_010376.1.
DR   AlphaFoldDB; B0S1C1; -.
DR   SMR; B0S1C1; -.
DR   STRING; 334413.FMG_0743; -.
DR   EnsemblBacteria; BAG08161; BAG08161; FMG_0743.
DR   KEGG; fma:FMG_0743; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001319; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..856
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000093627"
FT   BINDING         609..616
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   856 AA;  97638 MW;  E1D9260268708E52 CRC64;
     MAYTPMIKQY KEIKEQNKDC ILFFRLGDFY EMFFDDALIA SKELEIVLTQ RDCGENKKCP
     MCGIPYHVSD VYINKLVSKG YKVAICEQLE DPKLVKGLVK RGIIKIYTPA TVIENENSDT
     GNFNYLMSIS KKSNEVAISY IDISTGDVSY TNTTSDDIYK IIENEISKIT PKEIIFNDHE
     FSTNSLETIA SKFSIVLTTV NNGTDSIDFI NSKITYDNTN SETTNICVAN LLKYVFRYQD
     DLVHINSSRK YYINEFMEID SNSVINLEIQ KNLYTNSKNG SLFGVLNHTK TSMGSRLLHS
     YLERPLMDKE EILIRQNRVE EIFEDYELLV NLENCLDGIY DLDRLIAKLS YKSANAKDLI
     ALKVSIEKIP YLKNLLNCNK KNVQLIGEKL DDLRDIYDLI DKSIVDDPPV ILTEGNLIKP
     NFSNELDQLR YNRVNGKNEL VEYEMSEKDR LGIKNLKIVF NKKLGYFIDV TKSNLNKVGE
     DYEKRQTLTN SSRFKTKQLE AIESKILDSE DEIFELEYKI FEDIRKIILE NLSRIKKSAD
     LIAIIDVSNS LAKCAYLNNY IKPDINTYGL IDVLESRHPI VELSVGQSEF ITNDILIGSG
     KNDIQLITGP NMSGKSTYLR QVALICILNQ IGSFVPATKA NISIVDKIFT RIGSSDNLFK
     GESTFMVEMK EMSNIIKYAT SNSLLVLDEI GRGTSTYDGL SLAWAIVEYI SKDIKAKTLF
     ATHYHELTEL EKKLDNLINM KVDIKETNDS IIFLRKITRG STDKSYGIEV AELAGMPKTL
     IKRAKSILKE IDKEDTKIDL PIADFAVQNE MEDDKNIHEL KDFKDEIKNI NVNEITPIQS
     LQLLNELVIK ASKLGD