ID   MUTS_FLAJ1              Reviewed;         868 AA.
AC   A5FJ63;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Fjoh_1723;
OS   Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / JCM 8514 / NBRC
OS   14942 / NCIMB 11054 / UW101) (Cytophaga johnsonae).
OC   Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=376686;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17061 / DSM 2064 / JCM 8514 / NBRC 14942 / NCIMB 11054 / UW101;
RX   PubMed=19717629; DOI=10.1128/aem.01495-09;
RA   McBride M.J., Xie G., Martens E.C., Lapidus A., Henrissat B., Rhodes R.G.,
RA   Goltsman E., Wang W., Xu J., Hunnicutt D.W., Staroscik A.M., Hoover T.R.,
RA   Cheng Y.Q., Stein J.L.;
RT   "Novel features of the polysaccharide-digesting gliding bacterium
RT   Flavobacterium johnsoniae as revealed by genome sequence analysis.";
RL   Appl. Environ. Microbiol. 75:6864-6875(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABQ04755.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000685; ABQ04755.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_044047604.1; NZ_MUGZ01000024.1.
DR   AlphaFoldDB; A5FJ63; -.
DR   SMR; A5FJ63; -.
DR   STRING; 376686.Fjoh_1723; -.
DR   EnsemblBacteria; ABQ04755; ABQ04755; Fjoh_1723.
DR   KEGG; fjo:Fjoh_1723; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_10; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000006694; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..868
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335153"
FT   BINDING         620..627
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   868 AA;  97714 MW;  77233EA1FAFD35FF CRC64;
     MAAKEKVAKE TPLMKQYNEI KRKYPDACLL FRVGDFYETF GEDAIRASKI LGITLTKRGA
     GSDTETALAG FPHHSINTYL PKLVKAGLRV AICDQLEDPK MTKTIVKRGV TELVTPGVSL
     NDEVLQSKTN NFLASVCFAN KNIGISFLDV STGEFLTAQG NAEYIDKLLQ NFNPSEVLVP
     KNCKSEFKDA FGEDFHSFYL EDWIYKEDYA LETLTKHFQT NSLKGFGVEE LKEGIISAGA
     ILYYLSETQH NRVQHITAIQ RIAEDAYVWM DRFTIRNLEL YHSYNPNAVT LLDVIDKTLS
     PMGGRLLKRW LALPLKDTNK IKGRHAVVSY LKSNPEILHN IQYQIKQISD LERLISKIAA
     GKVSPREIVY LKESLDAIIP IKTLALESPQ EAVKVIGDSL HSCDLLREKI KTTLNQDAPV
     AISKGNAIAT GVNEELDELR AISTSGKEFL EGIERRESER TGISSLKISF NNVFGYYIEV
     RNTHKDKVPE EWIRKQTLVN AERYITEELK EYETKILGAE EKIHKIESEL FEQLVNWIAT
     YIKPVQMNAY LVAQLDCLCS FTQMAVENQY VCPEIDDTFE LDIKNGRHPV IEKQLPVGTP
     YIANDVFLDR EKQQIIMITG PNMSGKSAIL RQTALIVLLA QMGSFVPADS VRMGIVDKIF
     TRVGASDNIS MGESTFMVEM NETASILNNI SDRSLVLLDE IGRGTSTYDG ISIAWAIAEF
     LHEHPSKAKT LFATHYHELN EMTESLPRIQ NYNVAVKELK DTVLFVRKLV KGGSAHSFGI
     HVAKMAGMPQ LVISKAQKLL KKLEKNHSSD ALNGIKSAND EMQMSFFNLD DPLLEEIKEE
     ILSLDINAIT PVEALMKLNE IKRMLVKK