ID   MUTS_FLAPJ              Reviewed;         866 AA.
AC   A6GWN3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=FP0395;
OS   Flavobacterium psychrophilum (strain ATCC 49511 / DSM 21280 / CIP 103535 /
OS   JIP02/86).
OC   Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=402612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49511 / DSM 21280 / CIP 103535 / JIP02/86;
RX   PubMed=17592475; DOI=10.1038/nbt1313;
RA   Duchaud E., Boussaha M., Loux V., Bernardet J.-F., Michel C., Kerouault B.,
RA   Mondot S., Nicolas P., Bossy R., Caron C., Bessieres P., Gibrat J.-F.,
RA   Claverol S., Dumetz F., Le Henaff M., Benmansour A.;
RT   "Complete genome sequence of the fish pathogen Flavobacterium
RT   psychrophilum.";
RL   Nat. Biotechnol. 25:763-769(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM398681; CAL42506.1; -; Genomic_DNA.
DR   RefSeq; WP_011962564.1; NC_009613.3.
DR   RefSeq; YP_001295324.1; NC_009613.3.
DR   AlphaFoldDB; A6GWN3; -.
DR   SMR; A6GWN3; -.
DR   STRING; 402612.FP0395; -.
DR   EnsemblBacteria; CAL42506; CAL42506; FP0395.
DR   GeneID; 66551531; -.
DR   KEGG; fps:FP0395; -.
DR   PATRIC; fig|402612.5.peg.406; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_10; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000006394; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..866
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335154"
FT   BINDING         618..625
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   866 AA;  97456 MW;  73B74145CCC98BAE CRC64;
     MSTKEIKETP LMKQYNEIKR KYPDACLLFR VGDFYETFGD DAVRASKILG ITLTKRGAGS
     PTETALAGFP HHSINTYLPK LVKAGLRVAI CDQLEDPKMT KTIVKRGVTE LVTPGVSMND
     EVLNSKTNNF LASIYFGKKI IGVSFLDVST GEFLTSEGNE EYIDKLLQNF SPSEILVPKQ
     NKGDFKEKFG DNFHAFYLED WVYKEDYATE TLTNHFQTNS LKGFGIEELA SGIIASGAIL
     YYLSETQHNK IQHITSIHRI AEDAYVWMDR FTIRNLELYH SYNPNAVTLL DIIDKTLSPM
     GGRMLKRWLA LPLKNATIIK SRHEVVAYFK DHQEILQKVQ NQIKQISDLE RLISKVAAGR
     ISPREIIYLK ESLDAIIPIK ELALKSPQEA VKVIGDSLHS CDLLREKIKT TLNQEAPVAI
     SKGNAIAAGI HPELDELRGI SALGKEYLEG IEKRESEKTG ISSLKISFNN VFGYYIEVRN
     THKDKVPTEW IRKQTLVNAE RYITEELKEY ETKILGAEEK IQQIENQLFE QLVSWIATYI
     KPVQLNANLI AQLDCLISFT QLAIDNKYVC PQINDSFALD IKNGRHPVIE KQLPIGVPYI
     ANDVYLDRDT QQLIMITGPN MSGKSAILRQ TALIVLLAQM GSFVPAESVQ MGIVDKIFTR
     VGASDNISMG ESTFMVEMNE TASILNNISD RSLVLLDEIG RGTSTYDGVS IAWAIAEFLH
     ENPAQPKTLF ATHYHELNEM TESLPRIQNY NVSVKELKDT VLFIRKLVKG GSAHSFGIHV
     AKMAGMPQIV LQKAEKILKK LEKNHSAEAL SGTKGNKDDI QLSIFNLDDP LLEEIKEEIL
     NLDINTLTPV EALMKLNEIK RMLSKK