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MUTS_FRAP2
ID   MUTS_FRAP2              Reviewed;         848 AA.
AC   B0TX99;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Fphi_1133;
OS   Francisella philomiragia subsp. philomiragia (strain ATCC 25017 / FSC 153 /
OS   O#319-036).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC   Francisellaceae; Francisella.
OX   NCBI_TaxID=484022;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25017 / FSC 153 / O#319-036;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Richardson P.;
RT   "Complete sequence of chromosome of Francisella philomiragia subsp.
RT   philomiragia ATCC 25017.";
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000937; ABZ87357.1; -; Genomic_DNA.
DR   RefSeq; WP_012280515.1; NC_010336.1.
DR   AlphaFoldDB; B0TX99; -.
DR   SMR; B0TX99; -.
DR   STRING; 484022.Fphi_1133; -.
DR   EnsemblBacteria; ABZ87357; ABZ87357; Fphi_1133.
DR   KEGG; fph:Fphi_1133; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_1_6; -.
DR   OMA; TPMMAQY; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..848
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335155"
FT   BINDING         610..617
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   848 AA;  96128 MW;  A138F4FDA7034EED CRC64;
     MQEVSNHTPM IQQYLKIKSQ YPDILLFYRM GDFYELFFDD AKNAAELLDI TLTARGKSNG
     DSIPMAGVPY HAAEGYIAKI VKKGLSVAIC EQIGDPSTSK GPVERQVTRI ITPATVSEEA
     FLDSNQDSIL VSIYEKNNKY HIAYTSYTQG KIHLINTVTN SSDLKNQILK LSPQEIITNS
     NSLVEKNIFN KPVKVLEEWY FSNFEAKKHI LNSFDNSFAN NILNLYKKEQ LTVIGSILAY
     LTNTLKSTPK HISDILLDED QNILNIDINS RNNLELDNNS KSSLLNIMDK CKTSLGSRLL
     RRYFKNPTRD LNKISLRHNV IKSFKQHHYF LKIQDILSYI NDIERIISRV ALGTVKPKDL
     VSLNSSLEQL PKLKSLLEKI NTSEIININN HIHQIDELTK LLNKAIVDNP PMTIRDGGVI
     KHGFDQELDE LRGLKDNSYD FLLKFETLQK QKTGINTLKV GYNRVHGYYI ELSKQYADKV
     PTEYIRRQTL KASERYITDE LKAFEDKILS AKEKALAREK LIYDTLLNKV LEYYSQIQQT
     AASIAKIDVL ANFAERAIKL NLNQPKFNKT GKLDIKEARH LAIEQNIDEP FIPNDTLLST
     DTYTLEIITG PNMGGKSTYM RQVAQLIFLA YIGSFVPASY ADIGDIDTIY TRIGASDDIS
     SGRSTFMVEM TETAYILNNA TKKSLVIMDE IGRGTSTFDG LSLAKACAEK FAKIGAMTLF
     ATHYFELTEL VNQYPNTKNI HFEAKEYKDN IYFMHKAVAG AAKKSYGIQV AKLAGISKDV
     LDSAKKNLAN LEKGQDKLDT IDQPQQNLQL DQTPQKNHIK ERLETIDINS ITPIEALNIL
     FELKKTLI
 
 
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