MUTS_FRAP2
ID MUTS_FRAP2 Reviewed; 848 AA.
AC B0TX99;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Fphi_1133;
OS Francisella philomiragia subsp. philomiragia (strain ATCC 25017 / FSC 153 /
OS O#319-036).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC Francisellaceae; Francisella.
OX NCBI_TaxID=484022;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25017 / FSC 153 / O#319-036;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA Hauser L., Richardson P.;
RT "Complete sequence of chromosome of Francisella philomiragia subsp.
RT philomiragia ATCC 25017.";
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CP000937; ABZ87357.1; -; Genomic_DNA.
DR RefSeq; WP_012280515.1; NC_010336.1.
DR AlphaFoldDB; B0TX99; -.
DR SMR; B0TX99; -.
DR STRING; 484022.Fphi_1133; -.
DR EnsemblBacteria; ABZ87357; ABZ87357; Fphi_1133.
DR KEGG; fph:Fphi_1133; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_1_6; -.
DR OMA; TPMMAQY; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.110; -; 1.
DR Gene3D; 3.40.1170.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; PTHR11361; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; SSF48334; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF53150; SSF53150; 1.
DR SUPFAM; SSF55271; SSF55271; 1.
DR TIGRFAMs; TIGR01070; mutS1; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT CHAIN 1..848
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000335155"
FT BINDING 610..617
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 848 AA; 96128 MW; A138F4FDA7034EED CRC64;
MQEVSNHTPM IQQYLKIKSQ YPDILLFYRM GDFYELFFDD AKNAAELLDI TLTARGKSNG
DSIPMAGVPY HAAEGYIAKI VKKGLSVAIC EQIGDPSTSK GPVERQVTRI ITPATVSEEA
FLDSNQDSIL VSIYEKNNKY HIAYTSYTQG KIHLINTVTN SSDLKNQILK LSPQEIITNS
NSLVEKNIFN KPVKVLEEWY FSNFEAKKHI LNSFDNSFAN NILNLYKKEQ LTVIGSILAY
LTNTLKSTPK HISDILLDED QNILNIDINS RNNLELDNNS KSSLLNIMDK CKTSLGSRLL
RRYFKNPTRD LNKISLRHNV IKSFKQHHYF LKIQDILSYI NDIERIISRV ALGTVKPKDL
VSLNSSLEQL PKLKSLLEKI NTSEIININN HIHQIDELTK LLNKAIVDNP PMTIRDGGVI
KHGFDQELDE LRGLKDNSYD FLLKFETLQK QKTGINTLKV GYNRVHGYYI ELSKQYADKV
PTEYIRRQTL KASERYITDE LKAFEDKILS AKEKALAREK LIYDTLLNKV LEYYSQIQQT
AASIAKIDVL ANFAERAIKL NLNQPKFNKT GKLDIKEARH LAIEQNIDEP FIPNDTLLST
DTYTLEIITG PNMGGKSTYM RQVAQLIFLA YIGSFVPASY ADIGDIDTIY TRIGASDDIS
SGRSTFMVEM TETAYILNNA TKKSLVIMDE IGRGTSTFDG LSLAKACAEK FAKIGAMTLF
ATHYFELTEL VNQYPNTKNI HFEAKEYKDN IYFMHKAVAG AAKKSYGIQV AKLAGISKDV
LDSAKKNLAN LEKGQDKLDT IDQPQQNLQL DQTPQKNHIK ERLETIDINS ITPIEALNIL
FELKKTLI