ID   MUTS_FRATF              Reviewed;         844 AA.
AC   A7N9Y6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=FTA_0312;
OS   Francisella tularensis subsp. holarctica (strain FTNF002-00 / FTA).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC   Francisellaceae; Francisella.
OX   NCBI_TaxID=458234;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FTNF002-00 / FTA;
RX   PubMed=19756146; DOI=10.1371/journal.pone.0007041;
RA   Barabote R.D., Xie G., Brettin T.S., Hinrichs S.H., Fey P.D., Jay J.J.,
RA   Engle J.L., Godbole S.D., Noronha J.M., Scheuermann R.H., Zhou L.W.,
RA   Lion C., Dempsey M.P.;
RT   "Complete genome sequence of Francisella tularensis subspecies holarctica
RT   FTNF002-00.";
RL   PLoS ONE 4:E7041-E7041(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000803; ABU60789.1; -; Genomic_DNA.
DR   RefSeq; WP_003014457.1; NC_009749.1.
DR   AlphaFoldDB; A7N9Y6; -.
DR   SMR; A7N9Y6; -.
DR   KEGG; fta:FTA_0312; -.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..844
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335156"
FT   BINDING         610..617
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   844 AA;  95813 MW;  A87B7D80BA35143C CRC64;
     MQDISNHTPM IQQYLKIKSQ YQDILLFYRM GDFYELFFDD AKKAAELLDI TLTARGKSNG
     ESIPMAGVPY HAAEAYIAKI VKKGLSIAIC EQTGDPNTSK GPVERQVTRI ITPATVSEEA
     FLDNNQDSIL VSIFEKNNKY YLAYTSYTQG KIYLVKTLTS LNELKNTVLK LSPQEIITNS
     RELAQQNPFK KPIKALEEWY YSNFEAKKYI NDSLDTNIAN NILNLYKNDQ LTTIGSILSY
     LTNILKDTPR HITDISYEQE QDTLNIDINS RINLELDNNS KSSLLSIIGK CKTSLGSRLL
     KRYFSNPTRN LNILATRHSI INSLGENQHF LKIQDVLSYI SDIERIISRV ALGTVKPKDL
     VALRYSLEQL PILKKLLSEK NTPEITNINN RIHQLDELVT LLDKAIIENP PTTIRDGGVI
     KEGFDKELDE LKSIKDNSYD FLIKFEELQK QKIGISTLKV GYNRVHGYYI ELSKQHADKI
     PTEYVRRQTL KASERYITEE LKNFEDKVLS SKEKALAREK LIYDTLLKKV IEYYKQIQET
     AASIAEIDVL ANFAERAIKL KLSQPKFNNL AKLELKEVRH LAIEHNIDEP FIPNDTLLSK
     DTNTLQIITG PNMGGKSTYM RQVAQLIFLA YIGSFVPASY ADICDIDTIY TRIGASDDIS
     SGRSTFMVEM TETAYILNNA SAKSLVIMDE IGRGTSTFDG LALAKACAEK FAQMGAFTLF
     ATHYFELTEL AKQYPNVCNI HFEAKEYKDN IYFMHKAVTG AAKKSYGIQV AKLAGISQDV
     LESAKQNLYN LEKKQQLTES TQVQAQFQLE PTTQNPLQQK LDAIDINTIT PLEALNILFE
     LKKR