ID   MUTS_FRATM              Reviewed;         844 AA.
AC   B2SEQ6;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=FTM_0398;
OS   Francisella tularensis subsp. mediasiatica (strain FSC147).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC   Francisellaceae; Francisella.
OX   NCBI_TaxID=441952;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FSC147;
RX   PubMed=19521508; DOI=10.1371/journal.ppat.1000472;
RA   Larsson P., Elfsmark D., Svensson K., Wikstroem P., Forsman M., Brettin T.,
RA   Keim P., Johansson A.;
RT   "Molecular evolutionary consequences of niche restriction in Francisella
RT   tularensis, a facultative intracellular pathogen.";
RL   PLoS Pathog. 5:E1000472-E1000472(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000915; ACD30432.1; -; Genomic_DNA.
DR   RefSeq; WP_012429217.1; NC_010677.1.
DR   AlphaFoldDB; B2SEQ6; -.
DR   SMR; B2SEQ6; -.
DR   PRIDE; B2SEQ6; -.
DR   KEGG; ftm:FTM_0398; -.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..844
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000093628"
FT   BINDING         610..617
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   844 AA;  95735 MW;  93653CD9A58469D0 CRC64;
     MQDISNHTPM IQQYLKIKSQ YQDILLFYRM GDFYELFFDD AKKAAELLDI TLTARGKSNG
     ESIPMAGVPY HAAEAYIAKI VKKGLSIAIC EQTGDPNTSK GPVERQVTRI ITPATVSEEA
     FLDNNQDSIL VSIFEKNNKY YLAYTSYTQG KIYLVKTLTS LNELKNTVLK LSPQEIITNS
     RELAQQNPFK KPIKALEEWY YSNFEAKKYI NDSLDTNIAN NILNLYKNDK LTTIGSILSY
     LTNILKDTPR HITDISYEQE QDTLNIDINS RINLELDNNS KSSLLSIIGK CKTSLGSRLL
     KRYFSNPTRN LNILATRHSI INSLGENQHF LKIQDVLSYI SDIERIISRV ALGTVKPKDL
     VALRDSLEQL PILKKLLSEK NTPEITNINN RIHQLDELVT LLDKAIIENP PTTIRDGGVI
     KEGFDKELDE LKSIKDNSYD FLIKFEELQK QKTGISTLKV GYNRVHGYYI ELSKQHADKI
     PTEYVRRQTL KASERYITEE LKNFEDKVLS SKEKALAREK LIYDTLLKKV IEYYKQIQET
     AASIAEIDVL ANFAERAIKL KLSQPKFNNL AKLELKEVRH LAIEHNIDEP FIPNDTLLSK
     DTNTLQIITG PNMGGKSTYM RQVAQLIFLA YIGSFVPASY ADICDIDTIY TRIGASDDIS
     SGRSTFMVEM TETAYILNNA SAKSLVIMDE IGRGTSTFDG LALAKACAEK FAQIGAFTLF
     ATHYFELTEL AKQYPNVCNI HFEAKEYKDN IYFMHKAVTG AAKKSYGIQV AKLAGISQDV
     LESAKQNLYN LEKKQQLTES TQVQAQFQLE PTTQNPLQQK LDAIDINTIT PLEALNILFE
     LKKR