ID   MUTS_FRATN              Reviewed;         844 AA.
AC   A0Q809;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=FTN_1509;
OS   Francisella tularensis subsp. novicida (strain U112).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC   Francisellaceae; Francisella.
OX   NCBI_TaxID=401614;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=U112;
RX   PubMed=17550600; DOI=10.1186/gb-2007-8-6-r102;
RA   Rohmer L., Fong C., Abmayr S., Wasnick M., Larson Freeman T.J., Radey M.,
RA   Guina T., Svensson K., Hayden H.S., Jacobs M., Gallagher L.A., Manoil C.,
RA   Ernst R.K., Drees B., Buckley D., Haugen E., Bovee D., Zhou Y., Chang J.,
RA   Levy R., Lim R., Gillett W., Guenthener D., Kang A., Shaffer S.A.,
RA   Taylor G., Chen J., Gallis B., D'Argenio D.A., Forsman M., Olson M.V.,
RA   Goodlett D.R., Kaul R., Miller S.I., Brittnacher M.J.;
RT   "Comparison of Francisella tularensis genomes reveals evolutionary events
RT   associated with the emergence of human pathogenic strains.";
RL   Genome Biol. 8:R102.1-R102.16(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000439; ABK90374.1; -; Genomic_DNA.
DR   RefSeq; WP_004339137.1; NZ_CP009633.1.
DR   AlphaFoldDB; A0Q809; -.
DR   SMR; A0Q809; -.
DR   EnsemblBacteria; ABK90374; ABK90374; FTN_1509.
DR   GeneID; 60806704; -.
DR   KEGG; ftn:FTN_1509; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000762; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..844
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335158"
FT   BINDING         610..617
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   844 AA;  95756 MW;  9942051762BA5E1F CRC64;
     MQDISNHTPM IQQYLKIKSQ YQDILLFYRM GDFYELFFDD AKKAAELLDI TLTARGKSNG
     ESIPMAGVPY HAAEAYIAKI VKKGLSIAIC EQTGDPNTSK GPVERQVTRI ITPATVSEEA
     FLDSNQDSIL VSIFEKNNKY YLAYTSYTQG KIYLVKTLTS LNELKNTVLK LSPQEIITNS
     RELAQQNPFK KPIKALEEWY YSNFEAKKYI NDSLDTNIAN NILNLYKNDQ LTTIGSILSY
     LTNILKDTPR HITDISYEQE QDTLNIDINS RINLELDNSS KSSLLSIIGK CKTSLGSRLL
     KRYFSNPTRN LNILATRHNI INSLVENQHF LKIQDVLSYI SDIERIISRV ALGTVKPKDL
     VALRDSLEQL PILKKLLSEK NTPEITNINN RIHQLDELVT LLDKAIIENP PATIRDGGVI
     KEGFDKELDE LKSIKDNSYD FLIKFEELQK QKTGISTLKV GYNRVHGYYI ELSKQHADKI
     PTEYIRRQTL KASERYITEE LKNFEDKILS SKEKALAREK LIYETLLKKV IEYYKQIQET
     AASIAEIDVL ANFAERAIKL KLSQPKFNNL AKLELKEVRH LAIEHNIDEP FIPNDTLLSK
     DTNTLQIITG PNMGGKSTYM RQVAQLIFLA YIGSFVPASY ADICDIDTIY TRIGASDDIS
     SGRSTFMVEM TETAYILNNA SAKSLVIMDE IGRGTSTFDG LALAKACAEK FAQIGAFTLF
     ATHYFELTEL AKQYPNVCNI HFEAKEYKDN IYFMHKAVTG AAKKSYGIQV AKLAGISQDV
     LESAKQNLYN LEKKQHLAES TQIQAQFELE PTTQNPLQQK LDAIDINTIT PLEALNILFE
     LKKR