ID   MUTS_FRATO              Reviewed;         855 AA.
AC   Q0BNM7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=FTH_0294;
OS   Francisella tularensis subsp. holarctica (strain OSU18).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC   Francisellaceae; Francisella.
OX   NCBI_TaxID=393011;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OSU18;
RX   PubMed=16980500; DOI=10.1128/jb.00506-06;
RA   Petrosino J.F., Xiang Q., Karpathy S.E., Jiang H., Yerrapragada S., Liu Y.,
RA   Gioia J., Hemphill L., Gonzalez A., Raghavan T.M., Uzman A., Fox G.E.,
RA   Highlander S., Reichard M., Morton R.J., Clinkenbeard K.D., Weinstock G.M.;
RT   "Chromosome rearrangement and diversification of Francisella tularensis
RT   revealed by the type B (OSU18) genome sequence.";
RL   J. Bacteriol. 188:6977-6985(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000437; ABI82307.1; -; Genomic_DNA.
DR   RefSeq; WP_011648574.1; NC_017463.1.
DR   AlphaFoldDB; Q0BNM7; -.
DR   SMR; Q0BNM7; -.
DR   KEGG; fth:FTH_0294; -.
DR   OMA; TPMMAQY; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..855
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008062"
FT   BINDING         621..628
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   855 AA;  97164 MW;  78DA4908CFD189C5 CRC64;
     MLTKRFYNLA IMQDISNHTP MIQQYLKIKS QYQDILLFYR MGDFYELFFD DAKKAAELLD
     ITLTARGKSN GESIPMAGVP YHAAEAYIAK IVKKGLSIAI CEQTGDPNTS KGPVERQVTR
     IITPATVSEE AFLDNNQDSI LVSIFEKNNK YYLAYTSYTQ GKIYLVKTLT SLNELKNTVL
     KLSPQEIITN SRELAQQNPF KKPIKALEEW YYSNFEAKKY INDSLDTNIA NNILNLYKND
     QLTTIGSILS YLTNILKDTP RHITDISYEQ EQDTLNIDIN SRINLELDNN SKSSLLSIIG
     KCKTSLGSRL LKRYFSNPTR NLNILATRHS IINSLGENQH FLKIQDVLSY ISDIERIISR
     VALGTVKPKD LVALRYSLEQ LPILKKLLSE KNTPEITNIN NRIHQLDELV TLLDKAIIEN
     PPTTIRDGGV IKEGFDKELD ELKSIKDNSY DFLIKFEELQ KQKIGISTLK VGYNRVHGYY
     IELSKQHADK IPTEYVRRQT LKASERYITE ELKNFEDKVL SSKEKALARE KLIYDTLLKK
     VIEYYKQIQE TAASIAEIDV LANFAERAIK LKLSQPKFNN LAKLELKEVR HLAIEHNIDE
     PFIPNDTLLS KDTNTLQIIT GPNMGGKSTY MRQVAQLIFL AYIGSFVPAS YADICDIDTI
     YTRIGASDDI SSGRSTFMVE MTETAYILNN ASAKSLVIMD EIGRGTSTFD GLALAKACAE
     KFAQMGAFTL FATHYFELTE LAKQYPNVCN IHFEAKEYKD NIYFMHKAVT GAAKKSYGIQ
     VAKLAGISQD VLESAKQNLY NLEKKQQLTE STQVQAQFQL EPTTQNPLQQ KLDAIDINTI
     TPLEALNILF ELKKR