ID   MUTS_FRATT              Reviewed;         857 AA.
AC   Q5NEV8;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=FTT_1499;
OS   Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC   Francisellaceae; Francisella.
OX   NCBI_TaxID=177416;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SCHU S4 / Schu 4;
RX   PubMed=15640799; DOI=10.1038/ng1499;
RA   Larsson P., Oyston P.C.F., Chain P., Chu M.C., Duffield M., Fuxelius H.-H.,
RA   Garcia E., Haelltorp G., Johansson D., Isherwood K.E., Karp P.D.,
RA   Larsson E., Liu Y., Michell S., Prior J., Prior R., Malfatti S.,
RA   Sjoestedt A., Svensson K., Thompson N., Vergez L., Wagg J.K., Wren B.W.,
RA   Lindler L.E., Andersson S.G.E., Forsman M., Titball R.W.;
RT   "The complete genome sequence of Francisella tularensis, the causative
RT   agent of tularemia.";
RL   Nat. Genet. 37:153-159(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AJ749949; CAG46132.1; -; Genomic_DNA.
DR   RefSeq; YP_170434.1; NC_006570.2.
DR   AlphaFoldDB; Q5NEV8; -.
DR   SMR; Q5NEV8; -.
DR   IntAct; Q5NEV8; 1.
DR   STRING; 177416.FTT_1499; -.
DR   DNASU; 3192057; -.
DR   EnsemblBacteria; CAG46132; CAG46132; FTT_1499.
DR   KEGG; ftu:FTT_1499; -.
DR   eggNOG; COG0249; Bacteria.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001174; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..857
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224373"
FT   BINDING         621..628
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   857 AA;  97188 MW;  ED849D97506D2F92 CRC64;
     MLTKRFYNLA IMQDISNHTP MIQQYLKIKS QYQDILLFYR MGDFYELFFD DAKKAAELLD
     ITLTARGKSN GESIPMAGVP YHAAEAYIAK IVKKGLSIAI CEQTGDPNTS KGPVERQVTR
     IITPATVSEE AFLDNNQDSI LVSIFEKNNK YYLAYTSYTQ GKIYLVKTLT SLNELKNTVL
     KLSPQEIITN SRELAQQNPF KKPIKALEEW YYSNFEAKKY INDSLDTNIA NNILNLYKND
     QLTTIGSILS YLTNILKDTP RHITDISYEQ EQDTLNIDIN SRINLELDNN SKSSLLSIIG
     KCKTSLGSRL LKRYFSNPTR NLNILATRHS IINSLGENQH FLKIQDVLSY ISDIERIISR
     VALGTVKPKD LVALRDSLEQ LPILKKLLSE KNTPEITNIN NRIHQLDELV TLLDKAIIEN
     PPTTIRDGGV IKEGFDKELD ELKSIKDNSY DFLIKFEELQ KQKTGISTLK VGYNSVHGYY
     IELSKQHADK IPTEYVRRQT LKASERYITE ELKNFEDKVL SSKEKALARE KLIYDTLLKK
     VIEYYKQIQE TAASIAEIDV LANFAERAIK LKLSQPKFNN LAKLELKEVR HLAIEHNIDE
     PFIPNDTLLS KDTNTLQIIT GPNMGGKSTY MRQVAQLIFL AYIGSFVPAS YADICDIDTI
     YTRIGASDDI SSGRSTFMVE MTETAYILNN ASAKSLVIMD EIGRGTSTFD GLALAKACAE
     KFAQIGAFTL FATHYFELTE LAKQYPNVCN IHFEAKEYKD NIYFMHKAVT GAAKKSYGIQ
     VAKLAGISQD VLESAKQNLY NLEKKQQLTE STQVQAQFQL EPTTQNPLQQ KLDAIDINTI
     TPLEALNILF ELKKTLI