ID   MUTS_FUSNN              Reviewed;         896 AA.
AC   Q8RFK2;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=FN0693;
OS   Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 /
OS   BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355).
OC   Bacteria; Fusobacteria; Fusobacteriales; Fusobacteriaceae; Fusobacterium.
OX   NCBI_TaxID=190304;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC
RC   2640 / LMG 13131 / VPI 4355;
RX   PubMed=11889109; DOI=10.1128/jb.184.7.2005-2018.2002;
RA   Kapatral V., Anderson I., Ivanova N., Reznik G., Los T., Lykidis A.,
RA   Bhattacharyya A., Bartman A., Gardner W., Grechkin G., Zhu L., Vasieva O.,
RA   Chu L., Kogan Y., Chaga O., Goltsman E., Bernal A., Larsen N., D'Souza M.,
RA   Walunas T., Pusch G., Haselkorn R., Fonstein M., Kyrpides N.C.,
RA   Overbeek R.;
RT   "Genome sequence and analysis of the oral bacterium Fusobacterium nucleatum
RT   strain ATCC 25586.";
RL   J. Bacteriol. 184:2005-2018(2002).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AE009951; AAL94889.1; -; Genomic_DNA.
DR   RefSeq; NP_603590.1; NC_003454.1.
DR   AlphaFoldDB; Q8RFK2; -.
DR   SMR; Q8RFK2; -.
DR   STRING; 190304.FN0693; -.
DR   PRIDE; Q8RFK2; -.
DR   EnsemblBacteria; AAL94889; AAL94889; FN0693.
DR   KEGG; fnu:FN0693; -.
DR   PATRIC; fig|190304.8.peg.1258; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_10_0_0; -.
DR   InParanoid; Q8RFK2; -.
DR   OMA; TPMMAQY; -.
DR   BioCyc; FNUC190304:G1FZS-1279-MON; -.
DR   Proteomes; UP000002521; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..896
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115098"
FT   BINDING         638..645
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   896 AA;  102117 MW;  970C6BB08F1B6D22 CRC64;
     MLKYISYSEK RKIKLRGIKM SADTPLMQQY KKIKEEYQNE ILMFRLGDFY EMFFEDAKIA
     SKELGLTLTK RNREKGQDVP LAGVPYHSVA SYIAKLVEKG YSVAICDQVE DPKSATGIVK
     REVTRVITPG TIIDVDFLDK NNNNYIACIK INTTENIVAI AYTDITTGEF SVFEIKGKNF
     FEKALAEMNK IQASEILLDE KTYSEYIEIL KEKISFLGVK FTEVPNVRKA ESYLTSYFDI
     MSIEVFSLKS KDLAISTSAN LLHYIDELQK GNELPFSKIE YKNIDNIMEL NISTQNNLNL
     VPKRNEEAKG TLLGVLDNCV TSVGSRELKK IIKNPFLDIE KIKQRQFYVD YFYNDVLLRE
     NIREYLKDIY DVERIAGKII YGTENGKDLL SLKESIRKSL ETYKVLKEHQ EIKDILDIDV
     KILLDIYNKI ELIINIEAPF SVREGGIIKD GYNSELDKLR KISKLGKDFI LEIEQRERER
     TGIKGLKIKY NKVFGYFIEV TKANEHLVPE DYIRKQTLVN SERYIVPDLK EYEEKVITAK
     SKIEALEYEL FKQLTSEIKG HIDSLYKLAN RIANLDIVSN FAHIATKNSY VKPEIGDGDI
     LEIKGGRHPI VESLIPSGTY VKNDIILDDK NNLIILTGPN MSGKSTYMKQ VALNIIMAHI
     GSYVAADCAK IPIVDKIFTR VGASDDLLTG QSTFMLEMTE VASILNNATN KSFIVLDEIG
     RGTSTYDGIS IATAITEYIH NNIGAKTIFA THYHELTELE KELERAINFR VEVKEDGKNV
     VFLREIVKGG ADKSYGIEVA RLSGVPKEVL NRSNKILKKL ETRKNLIENK IKAEQMILFG
     NGFEEENEEE ETEILSENES KVLELLKNMD LNSLSPLESL LKLNELKKIL IGGTDE