ID   MUTS_GEOKA              Reviewed;         896 AA.
AC   Q5L0E5;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=GK1306;
OS   Geobacillus kaustophilus (strain HTA426).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus;
OC   Geobacillus thermoleovorans group.
OX   NCBI_TaxID=235909;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HTA426;
RX   PubMed=15576355; DOI=10.1093/nar/gkh970;
RA   Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H.,
RA   Matsui S., Uchiyama I.;
RT   "Thermoadaptation trait revealed by the genome sequence of thermophilic
RT   Geobacillus kaustophilus.";
RL   Nucleic Acids Res. 32:6292-6303(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; BA000043; BAD75591.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5L0E5; -.
DR   SMR; Q5L0E5; -.
DR   STRING; 235909.GK1306; -.
DR   EnsemblBacteria; BAD75591; BAD75591; GK1306.
DR   KEGG; gka:GK1306; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001172; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..896
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224374"
FT   BINDING         599..606
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   896 AA;  100665 MW;  1FD004C8A81758A6 CRC64;
     MIQQYLHIKA QYPDAFLFFR LGDFYELFFD DAIKAAQELE ITLTSRDGGD ERVPMCGVPY
     HSAQGYIEQL IEKGYKVAIC EQVEDPKTAK GVVRREVVQL ITPGTLMEGK GLTEKENHYL
     AALTPFADGT YGLAYADLST GEVRLTLLSS WEEAANELHA VGAREIIVAT DSGEEWVREL
     KERYGAAVSY EDDTSLCDEW NGVIGHVAQE KLRQAAARLL HYLVRTQKRR LDHLQPAELY
     QVDHYMKMDR HSKLHLELVE TVRSKGRKGS LLWLLDETVT AMGGRLLKQW LDRPLIDRRE
     IERRLDFVET LKTSYFERQE LRDRLRGVYD IERLVGRVSY GNANARDLVQ LKKSLLQVPA
     LRQTVGALPL AEADKLCERL DPCEELVDLL ERSIQEQPPL SVKEGNLIKD GYDKQLDRYR
     DASRNGKAWI AELEAKEREA TGIKSLKVGY NRVFGYYIEV TKPNLPLVPE GRYERKQTLA
     NAERFITPEL KEKEALILEA EEKSIELEYE LFVAIREQVK QYIPRLQTLA KAIAELDVLQ
     SFATISDEYR YVRPQFSTER VLVIQGGRHP VVEKVLGAQM YVPNDCYMNR EREMLLITGP
     NMAGKSTYMR QVALTAVMAQ IGCFVPAERA VLPIFDQVFT RIGAADDLSA GQSTFMVEML
     EARHAIAHAT QNSLILFDEI GRGTSTYDGM ALAQAIIEYI HDHIGAKTLF STHYHELTAL
     ERSLPRLSNV HARAIEENGK VVFLHQIADG PADKSYGIHV AELAGLPASL IERARAILAE
     LEKAAGKQEA AAGRMDDGAL AEAGLAFQGN EALDVGSKVE REKASRPSAG AAREGVLAEA
     AFEQLSMFPD LAPAPVEPPL SSKEKKALAA LKEINLLEMT PLEALNKLYE LQKLLK