ID   MUTS_GEOMG              Reviewed;         872 AA.
AC   Q39VR6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Gmet_1424;
OS   Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales;
OC   Geobacteraceae; Geobacter.
OX   NCBI_TaxID=269799;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 53774 / DSM 7210 / GS-15;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Di Bartolo G., Chain P., Schmutz J.,
RA   Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.;
RT   "Complete sequence of Geobacter metallireducens GS-15.";
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000148; ABB31658.1; -; Genomic_DNA.
DR   RefSeq; WP_004511644.1; NC_007517.1.
DR   AlphaFoldDB; Q39VR6; -.
DR   SMR; Q39VR6; -.
DR   STRING; 269799.Gmet_1424; -.
DR   EnsemblBacteria; ABB31658; ABB31658; Gmet_1424.
DR   KEGG; gme:Gmet_1424; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_7; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000007073; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..872
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008063"
FT   BINDING         622..629
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   872 AA;  96100 MW;  756D56A3BF95C812 CRC64;
     MSELTPMMRQ YLEIKADHPD SILFFRLGDF YEMFLDDAVK ASRILDITLT SRGKGGDGAD
     VPLCGVPYHS AAPYIAKLIE AGEKVAICEQ VEDPKTTKGI VKRQVVKVVT PGLVVESESL
     SPKENNFLLS LFDGNNGRWG VAYLDISTGE FRLTEVEGHD AAWGEVACAN PREILVPASF
     RENMRGEGRG DLAAGRTFTY VDDWVYDRDY TERLIKNHFG VASPGALGCD GYAEGLQAAA
     AVLHYLQETQ KGRVDHIREL RAYRTQEFLV LDEATRRNLE LTATLSEGKR RGSLLGLLDR
     TATAMGGRKL RQWINYPLVI VEKIKERQDA VGELANDPAL RAGIREALEG VYDLERLNGR
     ISLASSGAKD LVALKASLQR IPPLLSLLES TGTALLGELC KGIDPMDEVA ELIGRGIVDD
     PPFVLREGGI IADGYHAELD ELRAISREGK GFIARLEAKE KARTGITSLK IRYNKVFGYY
     IEVTKTNLGS IPEDYIRRQT LANAERFITP ELKEYEEKVL GAEERIVELE YSLFQQIRQS
     VAAEGERLAR TADRLATLDV LASLADVAHE RNYCRPGIDD GDTLSISEGR HPVVEALNVS
     ERFVPNDVLL DNGENQLVII TGPNMAGKST FMRQVALIVL MAQLGSFVPA TEARIGVVDR
     IFTRVGASDN LARGQSTFMV EMMETAAILR NATPKSLVVL DEIGRGTSTF DGVSIAWAVA
     EYLHDTARCA AKTLFATHYH ELTELAVTRG KIKNCNVAVK EWNDQVIFLR KIVEGGASHS
     YGIQVARLAG LPIEVIERAK EILHNLEKGE YVEGGVPRIS RGKRAAAPKS SPQLSLFEQG
     DDLLRQRLTG LNIAALTPLE ALNILDELKR MV